NOVA1
Sign in to saveAlso known as Nova-1, NOVA alternative splicing regulator 1
RNA-binding protein Nova-1 is a protein that in humans is encoded by the NOVA1 gene.
In the Vinony graph
Vinony's link graph records 9 inbound references to NOVA1, and connects out to PubMed, human chromosome 14 and Ensembl genome database project.
It is catalogued under the topic Genes on human chromosome 14.
Vinony links it to 8 Wikipedia language editions.
Gene data
NOVA1- Name
- NOVA alternative splicing regulator 1
- Type
- protein-coding
- Position
- 26,443,090–26,598,302 (−)
- Aliases
- Nova-1
- Ensembl
- ENSG00000139910
- RefSeq RNA
- NM_001366390.2, NM_001366391.2, NM_001366392.2, NM_001366393.2, NM_001366394.2
- RefSeq protein
- NP_001353319.1, NP_001353320.1, NP_001353321.1, NP_001353322.1, NP_001353323.1
This gene encodes a neuron-specific RNA-binding protein, a member of the Nova family of paraneoplastic disease antigens, that is recognized and inhibited by paraneoplastic antibodies. These antibodies are found in the sera of patients with paraneoplastic opsoclonus-ataxia, breast cancer, and small cell lung cancer. Alternatively spliced transcripts encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008].
Gene Ontology
Biological process
Molecular function
via MyGene.info
Gene · Ensembl
NOVA alternative splicing regulator 1
- Symbol
- NOVA1
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 14:26,443,090-26,598,302
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
- Image
- Protein NOVA1 PDB 1dt4.png
Show 8 more facts
- HomoloGene ID
- 21296
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/4857
- genomic end
- 27066960
- genomic start
- 26912299
- chromosome
- human chromosome 14
- cytogenetic location
- 14q12
- expressed in
- synovial joint
Sources (4)
via Wikidata · CC0
~1 min read
Encyclopedic overview
2 sectionsContents
- References
- Further reading
RNA-binding protein Nova-1 is a protein that in humans is encoded by the NOVA1 gene.
This gene encodes a neuron-specific RNA-binding protein, a member of the Nova family of paraneoplastic disease antigens, that is recognized and inhibited by paraneoplastic antibodies. These antibodies are found in the sera of patients with paraneoplastic opsoclonus-ataxia, breast cancer, and small cell lung cancer. Alternatively spliced transcripts encoding distinct isoforms have been described. Both Neanderthals and Denisovans had one version and nearly all modern humans had another suggesting positive selection. Insertion of Neanderthal gene variant of the neuro-oncological ventral antigen 1 (NOVA1) gene into human cortical organoids might promote slower development and higher surface complexity in the brain models, but this may be an artefact of a CRISPR side effect, as it could not be replicated in a subsequent study.
Excerpted from Wikipedia’s “NOVA1” article, available under the CC BY-SA 4.0 licence.