سیاهاپسین
Sign in to saveAlso known as Opsin-4, melanopsin, OPN4
Melanopsin is a type of photopigment belonging to a larger family of light-sensitive retinal proteins called opsins and encoded by the gene Opn4. In the mammalian retina, there are two additional categories of opsins, both involved in the formation of visual images: rhodopsin and photopsin (types I, II, and III) in the rod and cone photoreceptor cells, respectively.
Protein · UniProt
Melanopsin
- Gene
- OPN4
- Organism
- Homo sapiens (Human)
- Length
- 478 aa
- Molecular mass
- 52,635 Da
- Evidence
- 1: Evidence at protein level
G protein-coupled photoreceptor that signals through the G(q/11) family of G proteins in response to light in intrinsically photosensitive retinal ganglion cells (ipRGCs) (By similarity). Can also activate other G proteins, including G(i/o) and G(s), depending on the cell type, leading to either activation or inhibition of adenylate cyclase and cAMP-dependent signaling (PubMed:35274137). Activation occurs when opsin-bound cis-retinal chromophore absorbs a photon and isomerizes to all-trans-retinal, inducing a conformational change in the opsin that triggers a G protein-mediated phototransdu…
Swiss-Prot (reviewed) · via UniProt
Research
2,422 papers- Opsin 3 in keratinocytes mediates the light-induced exaggeration of atopic dermatitis.The Journal of allergy and clinical immunology · 2025
- Violet-light suppression of thermogenesis by opsin 5 hypothalamic neurons.Nature · 2020
- Retinal phototransduction.Neurosciences (Riyadh, Saudi Arabia) · 2014
- Multi-Characteristic Opsin Therapy to Functionalize Retina, Attenuate Retinal Degeneration, and Restore Vision in Mouse Models of Retinitis Pigmentosa.Translational vision science & technology · 2024
- Hypothalamic opsin 3 suppresses MC4R signaling and potentiates Kir7.1 to promote food consumption.Proceedings of the National Academy of Sciences of the United States of America · 2025
via PubMed
Clinical Trials
7 registered- UNKNOWNChromatic Pupillometry to Assess the Melanopsin-Light Pathway in Progressive Supranuclear PalsyMassachusetts General Hospital · NCT03330353
- NACOMPLETEDBlue Enriched Versus Standard Light Treatment for Seasonal Affective Disorder(SAD)University Medical Center Groningen · NCT01048294
- NATERMINATEDThin Film Spectacle Coatings to Reduce Light Sensitivity and Headaches in Child and Adolescent Patients With MigraineUniversity of Utah · NCT01942486
- NACOMPLETEDThe Effect of Induced Hyperammonaemia on Sleep and Melanopsin-mediated Pupillary Light Response in Patients With Liver CirrhosisRigshospitalet, Denmark · NCT04771104
- NACOMPLETEDEffects of Light on the Choroid and PupilUniversity of Houston · NCT05852782
- COMPLETEDThe Flashing Light-Induced Pupil Response (FLIPR) Glaucoma StudyOhio State University · NCT01857440
Wikidata facts
- Instance of
- protein
Show 3 more facts
- exact match
- purl.uniprot.org/uniprot/Q9UHM6
- found in taxon
- Homo sapiens
- Commons category
- Melanopsin
via Wikidata · CC0