Structure via PubChem · Public domain (PubChem)
اورفورگلیپرون
Sign in to saveOrforglipron, sold under the brand name Foundayo, is an oral, non-peptide, small-molecule GLP-1 receptor agonist developed as a weight loss drug by Eli Lilly and Company. It was discovered by Chugai Pharmaceutical Co., then was licensed to Lilly in 2018.
Chemical data
- Formula
- C48H48F2N10O5
- Molecular weight
- 883 g/mol
- IUPAC name
- 3-[(1S,2S)-1-[5-[(4S)-2,2-dimethyloxan-4-yl]-2-[(4S)-2-(4-fluoro-3,5-dimethylphenyl)-3-[3-(4-fluoro-1-methylindazol-5-yl)-2-oxoimidazol-1-yl]-4-methyl-6,7-dihydro-4H-pyrazolo[4,3-c]pyridine-5-carbonyl]indol-1-yl]-2-methylcyclopropyl]-4H-1,2,4-oxadiazol-5-one
- SMILES
- C[C@H]1C[C@]1(C2=NOC(=O)N2)N3C4=C(C=C(C=C4)[C@H]5CCOC(C5)(C)C)C=C3C(=O)N6CCC7=NN(C(=C7[C@@H]6C)N8C=CN(C8=O)C9=C(C1=C(C=C9)N(N=C1)C)F)C1=CC(=C(C(=C1)C)F)C
- InChIKey
- USUWIEBBBWHKNI-KHIFEHGGSA-N
- XLogP
- 6.8
- Polar surface area
- 144 Ų
- H-bond donors
- 1
- H-bond acceptors
- 10
- Formal charge
- 0
via PubChem
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 882.377721076
- Manufacturer
- Eli Lilly and Company
Show 4 more facts
- Commons category
- Orforglipron
- isomeric SMILES
- Cc1cc(-n2nc3c(c2-n2ccn(-c4ccc5c(cnn5C)c4F)c2=O)[C@H](C)N(C(=O)c2cc4cc([C@H]5CCOC(C)(C)C5)ccc4n2[C@@]2(c4nc(=O)o[nH]4)C[C@@H]2C)CC3)cc(C)c1F
- chemical formula
- C₄₈H₄₈F₂N₁₀O₅
- canonical SMILES
- Cc1cc(-n2nc3c(c2-n2ccn(-c4ccc5c(cnn5C)c4F)c2=O)C(C)N(C(=O)c2cc4cc(C5CCOC(C)(C)C5)ccc4n2C2(c4nc(=O)o[nH]4)CC2C)CC3)cc(C)c1F
via Wikidata · CC0