oritavancin
Sign in to saveAlso known as LY-333328, Chlorobiphenyl-chloroeremomycin
Oritavancin, sold under the brand name Orbactiv among others, is a semisynthetic glycopeptide antibiotic medication for the treatment of serious Gram-positive bacterial infections. Its chemical structure as a lipoglycopeptide is similar to vancomycin.
Key facts
- Drug.image
- Oritavancin.svg
- Drug.image_class
- skin-invert-image
- Drug.tradename
- Orbactiv, others
- Drug.MedlinePlus
- a614042
- Drug.DailyMedID
- Oritavancin
- Drug.routes_of_administration
- Intravenous
- Drug.ATC_prefix
- J01
- Drug.ATC_suffix
- XA05
- Drug.legal_CA
- Rx-only
- Drug.legal_US
- Rx-only
- Drug.legal_EU
- Rx-only
- Drug.CAS_number
- 171099-57-3
- Drug.PubChem
- 16131319
- Drug.DrugBank
- DB04911
- Drug.ChemSpiderID
- 31149229
- Drug.UNII
- PUG62FRZ2E
- Drug.KEGG
- D05271
- Drug.ChEBI
- 82699
via Wikipedia infobox
Research
545 papers- Oritavancin.2006
- Oritavancin: A Novel Lipoglycopeptide.The Consultant pharmacist : the journal of the American Society of Consultant Pharmacists · 2016
- Oritavancin: A Long-Half-Life Lipoglycopeptide.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2015
- Antibiotic penetration into bone and joints: An updated review.International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2019
- Oritavancin for acute bacterial skin and skin structure infections.Expert opinion on pharmacotherapy · 2015
via PubMed
Wikidata facts
- Mass
- 1790.564106
Show 3 more facts
- chemical formula
- C₈₆H₉₇Cl₃N₁₀O₂₆
- canonical SMILES
- CC1C(C(CC(O1)OC2C3C(=O)NC(C4=CC(=CC(=C4C5=C(C=CC(=C5)C(C(=O)N3)NC(=O)C6C7=CC(=C(C(=C7)OC8=C(C=C(C=C8)C(C(C(=O)NC(C(=O)N6)CC(=O)N)NC(=O)C(CC(C)C)NC)O)Cl)OC9C(C(C(C(O9)CO)O)O)OC1CC(C(C(O1)C)O)(C)NCC1=CC=C(C=C1)C1=CC=C(C=C1)Cl)OC1=C(C=C2C=C1)Cl)O)O)O)C(=O)O)(C)N)O
- isomeric SMILES
- CN[C@H](CC(C)C)C(=O)N[C@@H]1[C@H](O)C2=CC(Cl)=C(OC3=C(O[C@@H]4O[C@H](CO)[C@@H](O)[C@H](O)[C@H]4O[C@H]5C[C@](C)(NCC6=CC=C(C=C6)C7=CC=C(Cl)C=C7)[C@@H](O)[C@H](C)O5)C8=CC(=C3)[C@@H](NC(=O)[C@H](CC(N)=O)NC1=O)C(=O)N[C@@H]9C%10=CC=C(O)C(=C%10)C%11=C(C=C(O)C=C%11O)[C@H](NC(=O)[C@@H](NC9=O)[C@H](O[C@H]%12C[C@](C)(N)[C@@H](O)[C@H](C)O%12)C%13=CC(Cl)=C(O8)C=C%13)C(O)=O)C=C2
Sources (2)
via Wikidata · CC0
~4 min read
Article
7 sectionsContents
- Medical uses
- ''In vitro'' activity
- Mechanism
- Synergism
- Spectrum of Activity
- History
- References
Oritavancin, sold under the brand name Orbactiv among others, is a semisynthetic glycopeptide antibiotic medication for the treatment of serious Gram-positive bacterial infections. Its chemical structure as a lipoglycopeptide is similar to vancomycin.
The US Food and Drug Administration and the European Medicines Agency approved oritavancin for treatment of acute bacterial skin and skin structure infections.