OTUB2
Sign in to saveAlso known as C14orf137, OTB2, OTU2, OTU deubiquitinase, ubiquitin aldehyde binding 2
Ubiquitin thioesterase OTUB2 is an enzyme that in humans is encoded by the OTUB2 gene.
Gene data
OTUB2- Name
- OTU deubiquitinase, ubiquitin aldehyde binding 2
- Type
- protein-coding
- Aliases
- C14orf137, OTB2, OTU2
This gene encodes one of several deubiquitylating enzymes. Ubiquitin modification of proteins is needed for their stability and function; to reverse the process, deubiquityling enzymes remove ubiquitin. This protein contains an OTU domain and binds Ubal (ubiquitin aldehyde); an active cysteine protease site is present in the OTU domain. [provided by RefSeq, Aug 2011].
via MyGene.info
Wikidata facts
- Image
- Protein OTUB2 PDB 1tff.png
Show 5 more facts
- HomoloGene ID
- 57056
- exact match
- identifiers.org/ncbigene/78990
- genomic start
- 94026340
- genomic end
- 94515276
- cytogenetic location
- 14q32.12
Sources (4)
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Article
2 sectionsContents
- References
- Further reading
Ubiquitin thioesterase OTUB2 is an enzyme that in humans is encoded by the OTUB2 gene.
Otubains are deubiquitinating cysteine proteases (DUBs; see MIM 602519) that belong to the ovarian tumor (OTU) protein superfamily. Like other DUBs, otubains cleave proteins precisely at the ubiquitin (UB; see MIM 191339)-protein bond.