OTUB2

Also known as C14orf137, OTB2, OTU2, OTU deubiquitinase, ubiquitin aldehyde binding 2

Ubiquitin thioesterase OTUB2 is an enzyme that in humans is encoded by the OTUB2 gene.

In the Vinony graph

Vinony's link graph records 2 inbound references to OTUB2, and connects out to PubMed, human chromosome 14 and Ensembl genome database project.

It is catalogued under the topic Genes on human chromosome 14.

Vinony links it to 5 Wikipedia language editions.

Gene data

OTUB2

Name: OTU deubiquitinase, ubiquitin aldehyde binding 2
Type: protein-coding
Position: 94,026,329–94,049,618 (+)
Aliases: C14orf137, OTB2, OTU2
Ensembl: ENSG00000277276
RefSeq RNA: NM_023112.4
RefSeq protein: NP_075601.1

This gene encodes one of several deubiquitylating enzymes. Ubiquitin modification of proteins is needed for their stability and function; to reverse the process, deubiquityling enzymes remove ubiquitin. This protein contains an OTU domain and binds Ubal (ubiquitin aldehyde); an active cysteine protease site is present in the OTU domain. [provided by RefSeq, Aug 2011].

Gene Ontology

Biological process

protein deubiquitination protein deubiquitination protein K11-linked deubiquitination protein K63-linked deubiquitination protein K48-linked deubiquitination protein K48-linked deubiquitination

Molecular function

cysteine-type deubiquitinase activity cysteine-type deubiquitinase activity cysteine-type deubiquitinase activity cysteine-type deubiquitinase activity protein binding hydrolase activity ubiquitin binding

Cellular component

nucleus

Pathways

Metabolism of proteins Deubiquitination Ovarian tumor domain proteases Post-translational protein modification

via MyGene.info

Gene · Ensembl

OTU deubiquitinase, ubiquitin aldehyde binding 2

Symbol: OTUB2
Biotype: Protein coding
Organism: Homo sapiens
Location: 14:94,026,329-94,049,618
Strand: Forward (+)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Instance of: gene
Image: Protein OTUB2 PDB 1tff.png

Show 8 more facts

HomoloGene ID: 57056
found in taxon: Homo sapiens
exact match: identifiers.org/ncbigene/78990
chromosome: human chromosome 14
genomic start: 94026340
genomic end: 94515276
cytogenetic location: 14q32.12
expressed in: islet of Langerhans

Sources (4)

via Wikidata · CC0

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Encyclopedic overview

2 sections

Contents

References
Further reading

Ubiquitin thioesterase OTUB2 is an enzyme that in humans is encoded by the OTUB2 gene.

Otubains are deubiquitinating cysteine proteases (DUBs; see MIM 602519) that belong to the ovarian tumor (OTU) protein superfamily. Like other DUBs, otubains cleave proteins precisely at the ubiquitin (UB; see MIM 191339)-protein bond.

Excerpted from Wikipedia’s “OTUB2” article, available under the CC BY-SA 4.0 licence.