File:Pantoprazole.svg · Wikimedia Commons · See Wikimedia Commons
pantoprazole
Sign in to saveAlso known as PAN023, BY-1023, SK-96022, 6-(difluoromethoxy)-2-{[(3,4-dimethoxypyridin-2-yl)methane]sulfinyl}-1H-1,3-benzodiazole
Pantoprazole, sold under the brand name Protonix, among others, is a medication used for the treatment of stomach ulcers, short-term treatment of erosive esophagitis due to gastroesophageal reflux disease (GERD), maintenance of healing of erosive esophagitis, and pathological hypersecretory conditions including Zollinger–Ellison syndrome. It may also be used along with other medications to eliminate Helicobacter pylori. Pantoprazole is a proton-pump inhibitor (PPI) and its effectiveness is similar to that of other PPIs. It is available by mouth and by injection into a vein.
OverviewAI-generated
Pantoprazole is a chemical compound with the formula C₁₆H₁₅F₂N₃O₄S. Its IUPAC name is 6-(difluoromethoxy)-2-[(3,4-dimethoxy-2-pyridinyl)methylsulfinyl]-1H-benzimidazole. The substance has a mass of 383.075133 and a weight of 383.4. It possesses a charge of 0, an xlogp value of 2.4, and a topological polar surface area of 106. The molecule contains one hydrogen bond donor and nine hydrogen bond acceptors.
The defined daily dose for pantoprazole is 40. The compound is referenced by 98 other encyclopedia articles. A search for pantoprazole in PubMed yields a count of 2729 entries.
Synthesized by Vinony from 18 facts across 4 sources: Wikidata, PubMed, PubChem, Vinony graph. Generated from structured data (not the Wikipedia text) and checked against those facts — may still contain errors.
Key facts
- Drug.N
- 3
- Drug.O
- 4
- Drug.S
- 1
- Drug.Watchedfields
- changed
- Drug.verifiedrevid
- 462272670
- Drug.image
- Pantoprazole.svg
- Drug.image_class
- skin-invert-image
- Drug.width
- 245
- Drug.chirality
- Racemic
- Drug.caption
- Above: molecular structure of pantoprazole Below: 3D representation of a pantoprazole molecule
- Drug.image2
- Pantoprazole 3D.png
- Drug.image_class2
- bg-transparent
- Drug.tradename
- Protonix, others
- Drug.MedlinePlus
- a601246
- Drug.DailyMedID
- Pantoprazole
- Drug.pregnancy_AU
- B3
- Drug.routes_of_administration
- By mouth and intravenous
- Drug.class
- Proton-pump inhibitor
via Wikipedia infobox
Chemical data
- Formula
- C16H15F2N3O4S
- Molecular weight
- 383.4 g/mol
- IUPAC name
- 6-(difluoromethoxy)-2-[(3,4-dimethoxy-2-pyridinyl)methylsulfinyl]-1H-benzimidazole
- SMILES
- COC1=C(C(=NC=C1)CS(=O)C2=NC3=C(N2)C=C(C=C3)OC(F)F)OC
- InChIKey
- IQPSEEYGBUAQFF-UHFFFAOYSA-N
- XLogP
- 2.4
- Polar surface area
- 106 Ų
- H-bond donors
- 1
- H-bond acceptors
- 9
- Formal charge
- 0
via PubChem
Research
2,729 papers- Pantoprazole.American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists · 2001
- Pantoprazole: a proton pump inhibitor.Clinical drug investigation · 2009
- Comparison of the effects of esomeprazole 40 mg, rabeprazole 20 mg, lansoprazole 30 mg, and pantoprazole 40 mg on intragastrıc pH in extensive metabolizer patients with gastroesophageal reflux disease.The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology · 2016
- Pantoprazole based therapies in Helicobacter pylori eradication: a systematic review and meta-analysis.European journal of gastroenterology & hepatology · 2004
- Pantoprazole: a new proton pump inhibitor.Clinical therapeutics · 2000
via PubMed
~15 min read
Encyclopedic overview
17 sectionsContents
- Medical uses
- Children
- Adverse effects
- Infection
- Elderly
- Pregnancy
- Breast feeding
- Common
- Rare
- Long-term use
- Discontinuation
- Interactions
- Pharmacology
- History
- Society and culture
- Veterinary use
- References
Pantoprazole, sold under the brand name Protonix, among others, is a medication used for the treatment of stomach ulcers, short-term treatment of erosive esophagitis due to gastroesophageal reflux disease (GERD), maintenance of healing of erosive esophagitis, and pathological hypersecretory conditions including Zollinger–Ellison syndrome. It may also be used along with other medications to eliminate Helicobacter pylori. Pantoprazole is a proton-pump inhibitor (PPI) and its effectiveness is similar to that of other PPIs. It is available by mouth and by injection into a vein.
Common side effects include headaches, diarrhea, abdominal pain, and joint pain. More serious side effects may include severe allergic reactions, a type of chronic inflammation known as atrophic gastritis, Clostridioides difficile colitis, low magnesium, and vitamin B12 deficiency. Use in pregnancy appears to be safe. Pantoprazole is a proton pump inhibitor that decreases gastric acid secretion. It works by inactivating (H+/K+)-ATPase function in the stomach.
Excerpted from Wikipedia’s “pantoprazole” article, available under the CC BY-SA 4.0 licence.