Structure via PubChem · Public domain (PubChem)
vonoprazan
Sign in to saveVonoprazan, sold under the brand name Voquezna among others, is a first-in-class potassium-competitive acid blocker medication. Vonoprazan is used in form of the fumarate for the treatment of gastroduodenal ulcer (including some drug-induced peptic ulcers) and reflux esophagitis, and can be combined with antibiotics for the eradication of Helicobacter pylori.
Chemical data
- Formula
- C17H16FN3O2S
- Molecular weight
- 345.4 g/mol
- IUPAC name
- 1-[5-(2-fluorophenyl)-1-pyridin-3-ylsulfonylpyrrol-3-yl]-N-methylmethanamine
- SMILES
- CNCC1=CN(C(=C1)C2=CC=CC=C2F)S(=O)(=O)C3=CN=CC=C3
- InChIKey
- BFDBKMOZYNOTPK-UHFFFAOYSA-N
- XLogP
- 2
- Polar surface area
- 72.4 Ų
- H-bond donors
- 1
- H-bond acceptors
- 5
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Approved
- Molecule type
- Small molecule
- First approval
- 2022
- Admin. routes
- oral
- Indications
- gastroesophageal reflux disease, Helicobacter pylori infectious disease, Peptic ulcer, esophagitis
via ChEMBL · EBI
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 345.094725972
Show 3 more facts
- Commons category
- Vonoprazan
- chemical formula
- C₁₇H₁₆FN₃O₂S
- canonical SMILES
- CNCC1=CN(C(=C1)C2=CC=CC=C2F)S(=O)(=O)C3=CN=CC=C3
Sources (2)
via Wikidata · CC0
~2 min read
Encyclopedic overview
6 sectionsContents
- Medical uses
- Adverse effects
- Society and culture
- Names
- References
- External links
Vonoprazan, sold under the brand name Voquezna among others, is a first-in-class potassium-competitive acid blocker medication. Vonoprazan is used in form of the fumarate for the treatment of gastroduodenal ulcer (including some drug-induced peptic ulcers) and reflux esophagitis, and can be combined with antibiotics for the eradication of Helicobacter pylori.
It was approved in Japan in February 2015, and in Russia in April 2021. Vonoprazan was approved for medical use in the United States in November 2023. Co-packaged combinations of vonoprazan with amoxicillin and vonoprazan with amoxicillin and clarithromycin are available.
Excerpted from Wikipedia’s “vonoprazan” article, available under the CC BY-SA 4.0 licence.