PDCD1LG2
Sign in to saveAlso known as B7DC, Btdc, CD273, PD-L2, PDCD1L2, PDL2, bA574F11.2, programmed cell death 1 ligand 2
Programmed cell death 1 ligand 2 (also known as PD-L2, B7-DC) is a protein that in humans is encoded by the PDCD1LG2 gene. PDCD1LG2 has also been designated as CD273 (cluster of differentiation 273). PDCD1LG2 is an immune checkpoint receptor ligand which plays a role in negative regulation of the adaptive immune response. PD-L2 is one of two known ligands for Programmed cell death protein 1 (PD-1), the other one being PD-L1 to which it is related by a gene duplication in an ancestor of tetrapod species.
Gene data
PDCD1LG2- Name
- programmed cell death 1 ligand 2
- Type
- protein-coding
- Aliases
- B7DC, Btdc, CD273, PD-L2, PDCD1L2, PDL2, bA574F11.2
Involved in negative regulation of activated T cell proliferation; negative regulation of interferon-gamma production; and negative regulation of interleukin-10 production. Predicted to be located in plasma membrane. Predicted to be active in external side of plasma membrane. Biomarker of pulmonary tuberculosis. [provided by Alliance of Genome Resources, Apr 2022]
via MyGene.info
Gene · Ensembl
programmed cell death 1 ligand 2
- Symbol
- PDCD1LG2
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 9:5,485,745-5,571,282
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
~4 min read
Encyclopedic overview
9 sectionsContents
- Structure
- Expression
- Profile
- Regulation
- Function
- Clinical significance
- References
- Further reading
- External links
Programmed cell death 1 ligand 2 (also known as PD-L2, B7-DC) is a protein that in humans is encoded by the PDCD1LG2 gene. PDCD1LG2 has also been designated as CD273 (cluster of differentiation 273). PDCD1LG2 is an immune checkpoint receptor ligand which plays a role in negative regulation of the adaptive immune response. PD-L2 is one of two known ligands for Programmed cell death protein 1 (PD-1), the other one being PD-L1 to which it is related by a gene duplication in an ancestor of tetrapod species.
== Structure == left|thumb|X-ray crystallography structure of high affinity mutant hPDL2-hPD1 complex (1.986 Å) reported in Tang and Kim, PNAS 2019. hPD-1: green/blue, hPD-L2: red/orange/yellow|link=File:PDL2-PD1highaffinity.gif
Excerpted from Wikipedia’s “PDCD1LG2” article, available under the CC BY-SA 4.0 licence.