PDGFRB

Name

platelet derived growth factor receptor beta

Type

protein-coding

Position

150,113,839–150,186,363 (−)

Aliases

CD140B, IBGC4, IMF1, JTK12, KOGS, OPDKD, PDGFR, PDGFR-1, PDGFR1, PENTT

Ensembl

ENSG00000113721

RefSeq RNA

NM_001355016.2, NM_001355017.2, NM_002609.4, NR_149150.2

RefSeq protein

NP_001341945.1, NP_001341946.1, NP_002600.1

The protein encoded by this gene is a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer (PDGFB or PDGFD) or a heterodimer (PDGFA and PDGFB). This gene is essential for normal development of the cardiovascular system and aids in rearrangement of the actin cytoskeleton. This gene is flanked on chromosome 5 by the genes for granulocyte-macrophage colony-stimulating factor and macrophage-colony stimulating factor receptor; all three genes may be implicated in the 5-q syndrome. A translocation between chromosomes 5 and 12, that fuses this gene to that of the ETV6 gene, results in chronic myeloproliferative disorder with eosinophilia. [provided by RefSeq, Aug 2017].

via MyGene.info

Gene · Ensembl

platelet derived growth factor receptor beta

Symbol

PDGFRB

Biotype

Protein coding

Organism

Homo sapiens

Location

5:150,113,839-150,186,363

Strand

Reverse (−)

Assembly

GRCh38

Wikidata facts

Instance of

gene

Image

PDGFR-beta 3MJG.png

via Wikidata · CC0