pentetrazol
Sign in to saveAlso known as 7,8,9,10-tetrazabicyclo[5.3.0]-8,10-decadiene, 6,7,8,9-tetrahydro-5H-tetrazolo[1,5-a]azepine, 6,7,8,9-tetrahydro-5-azepotetrazole, 1,5-pentamethylenetetrazole, alpha,beta-cyclopentamethylenetetrazole, pentamethylene-1,5-tetrazole, pentylenetetrazol
Pentylenetetrazol (PTZ), also known as pentylenetetrazole, pentetrazol (INN), and pentamethylenetetrazol, is a drug formerly used as a circulatory and respiratory stimulant. High doses cause convulsions, as discovered by Hungarian-American neurologist and psychiatrist Ladislas J. Meduna in 1934. It has been used in convulsive therapy, and was found to be effective in treating depression, but side effects, such as uncontrolled seizures, were difficult to avoid. In 1939, pentylenetetrazol was replaced by electroconvulsive therapy, which is easier to administer, as the preferred method for induci
Key facts
- Drug.Verifiedfields
- changed
- Drug.Watchedfields
- changed
- Drug.INN
- Pentetrazol
- Drug.verifiedrevid
- 415933541
- Drug.IUPAC_name
- 6,7,8,9-Tetrahydro-5H-tetrazolo(1,5-a)azepine
- Drug.image
- Pentylenetetrazol.svg
- Drug.image_class
- skin-invert-image
- Drug.width
- 150
- Drug.image2
- File:Pentylenetetrazol ball-and-stick model.png
- Drug.image_class2
- bg-transparent
- Drug.tradename
- Metrazol, others
- Drug.CAS_number
- 54-95-5
- Drug.ATC_prefix
- R07
- Drug.ATC_suffix
- AB03
- Drug.PubChem
- 5917
- Drug.ChemSpiderID
- 5704
- Drug.UNII
- WM5Z385K7T
- Drug.ChEBI
- 34910
via Wikipedia infobox
Research
8,588 papers- Participation of metabotropic glutamate receptors in pentetrazol-induced kindled seizure.Epilepsia · 2011
- The Potential Mechanism of Cannabidiol (CBD) Treatment of Epilepsy in Pentetrazol (PTZ) Kindling Mice Uncovered by Multi-Omics Analysis.Molecules (Basel, Switzerland) · 2023
- Subconvulsive metrazol therapy.The Journal of nervous and mental disease · 1953
- The effects of trimethadione on pentetrazol-induced discharges of primary muscle spindle afferents from the hind limb of the rat.British journal of pharmacology · 1981
- Narco-stimulation.The American journal of psychiatry · 1959
via PubMed
Wikidata facts
- Mass
- 138.091
Show 5 more facts
- chemical formula
- C₆H₁₀N₄
- canonical SMILES
- C1CCC2=NN=NN2CC1
- World Health Organisation international non-proprietary name
- pentetrazol
- melting point
- 60
- Commons category
- Pentylenetetrazol
via Wikidata · CC0
~3 min read
Article
5 sectionsContents
- Side effects
- Mechanism of action
- Research
- See also
- References
Pentylenetetrazol (PTZ), also known as pentylenetetrazole, pentetrazol (INN), and pentamethylenetetrazol, is a drug formerly used as a circulatory and respiratory stimulant. High doses cause convulsions, as discovered by Hungarian-American neurologist and psychiatrist Ladislas J. Meduna in 1934. It has been used in convulsive therapy, and was found to be effective in treating depression, but side effects, such as uncontrolled seizures, were difficult to avoid. In 1939, pentylenetetrazol was replaced by electroconvulsive therapy, which is easier to administer, as the preferred method for inducing seizures in England's mental hospitals. In the US, pentylenetetrazol's approval by the Food and Drug Administration (FDA) was revoked in 1982. It is used in Italy as a cardio-respiratory stimulant in combination with dihydrocodeine in a cough suppressant drug.
==Side effects== Pentylenetetrazol is anxiogenic and has been known to induce severe anxiety in humans.