PES1

Also known as PES, pescadillo ribosomal biogenesis factor 1, NOP7

Pescadillo homolog is a protein that in humans is encoded by the PES1 gene.

In the Vinony graph

Vinony's link graph records 6 inbound references to PES1, and connects out to PubMed, human chromosome 22 and Ensembl genome database project.

It is catalogued under the topic Genes on human chromosome 22.

Vinony links it to 5 Wikipedia language editions.

Gene data

PES1

Name: pescadillo ribosomal biogenesis factor 1
Type: protein-coding
Position: 30,576,624–30,607,083 (−)
Aliases: NOP7, PES
Ensembl: ENSG00000100029
RefSeq RNA: NM_001243225.2, NM_001282327.1, NM_001282328.1, NM_014303.4
RefSeq protein: NP_001230154.1, NP_001269256.1, NP_001269257.1, NP_055118.1

This gene encodes a nuclear protein that contains a breast cancer associated gene 1 (BRCA1) C-terminal interaction domain. The encoded protein interacts with BOP1 and WDR12 to form the PeBoW complex, which plays a critical role in cell proliferation via pre-rRNA processing and 60S ribosomal subunit maturation. Expression of this gene may play an important role in breast cancer proliferation and tumorigenicity. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. Pseudogenes of this gene are located on the long arm of chromosome 4 and the short arm of chromosome 9. [provided by RefSeq, Aug 2011].

Pathways

Major pathway of rRNA processing in the nucleolus and cytosol rRNA processing rRNA processing in the nucleus and cytosol Metabolism of RNA

via MyGene.info

Gene · Ensembl

pescadillo ribosomal biogenesis factor 1

Symbol: PES1
Biotype: Protein coding
Organism: Homo sapiens
Location: 22:30,576,624-30,607,083
Strand: Reverse (−)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Instance of: gene

Show 7 more facts

HomoloGene ID: 5984
found in taxon: Homo sapiens
exact match: identifiers.org/ncbigene/23481
genomic end: 31003070
genomic start: 30972612
chromosome: human chromosome 22
cytogenetic location: 22q12.2

Sources (4)

via Wikidata · CC0

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Encyclopedic overview

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Contents

References
Further reading

Pescadillo homolog is a protein that in humans is encoded by the PES1 gene.

This gene encodes a protein that is abnormally elevated in malignant tumors of astrocytic origin. It is a strongly conserved gene containing a BRCT domain that is essential for the activity of this gene product. The gene plays a crucial role in cell proliferation and may be necessary for oncogenic transformation and tumor progression.

Excerpted from Wikipedia’s “PES1” article, available under the CC BY-SA 4.0 licence.