PES1

Also known as PES, pescadillo ribosomal biogenesis factor 1, NOP7

Pescadillo homolog is a protein that in humans is encoded by the PES1 gene.

Gene data

PES1

Name: pescadillo ribosomal biogenesis factor 1
Type: protein-coding
Aliases: NOP7, PES

This gene encodes a nuclear protein that contains a breast cancer associated gene 1 (BRCA1) C-terminal interaction domain. The encoded protein interacts with BOP1 and WDR12 to form the PeBoW complex, which plays a critical role in cell proliferation via pre-rRNA processing and 60S ribosomal subunit maturation. Expression of this gene may play an important role in breast cancer proliferation and tumorigenicity. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. Pseudogenes of this gene are located on the long arm of chromosome 4 and the short arm of chromosome 9. [provided by RefSeq, Aug 2011].

via MyGene.info

Gene · Ensembl

pescadillo ribosomal biogenesis factor 1

Symbol: PES1
Biotype: Protein coding
Organism: Homo sapiens
Location: 22:30,576,624-30,607,083
Strand: Reverse (−)
Assembly: GRCh38

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via Ensembl · EMBL-EBI

Wikidata facts

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HomoloGene ID: 5984
exact match: identifiers.org/ncbigene/23481
genomic end: 31003070
genomic start: 30972612
cytogenetic location: 22q12.2

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Pescadillo homolog is a protein that in humans is encoded by the PES1 gene.

This gene encodes a protein that is abnormally elevated in malignant tumors of astrocytic origin. It is a strongly conserved gene containing a BRCT domain that is essential for the activity of this gene product. The gene plays a crucial role in cell proliferation and may be necessary for oncogenic transformation and tumor progression.