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pexidartinib
Sign in to saveAlso known as PLX-3397, PLX3397
Pexidartinib, sold under the brand name Turalio, is a kinase inhibitor drug for the treatment of adults with symptomatic tenosynovial giant cell tumor (TGCT) associated with severe morbidity or functional limitations and not amenable to improvement with surgery. Pexidartinib blocks the activity of the colony-stimulating factor-1 receptor (CSF-1R).
Chemical data
- Formula
- C20H15ClF3N5
- Molecular weight
- 417.8 g/mol
- IUPAC name
- 5-[(5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)methyl]-N-[[6-(trifluoromethyl)-3-pyridinyl]methyl]pyridin-2-amine
- SMILES
- C1=CC(=NC=C1CC2=CNC3=C2C=C(C=N3)Cl)NCC4=CN=C(C=C4)C(F)(F)F
- InChIKey
- JGWRKYUXBBNENE-UHFFFAOYSA-N
- XLogP
- 4.5
- Polar surface area
- 66.5 Ų
- H-bond donors
- 2
- H-bond acceptors
- 7
- Formal charge
- 0
via PubChem
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 417.097
- Has use
- medication
Show 4 more facts
- canonical SMILES
- C1=CC(=NC=C1CC2=CNC3=NC=C(C=C23)Cl)NCC4=CN=C(C=C4)C(F)(F)F
- chemical formula
- C₂₀H₁₅ClF₃N₅
- legal status (medicine)
- boxed warning
- subject has role
- protein kinase inhibitors
via Wikidata · CC0
~5 min read
Encyclopedic overview
4 sectionsContents
- History
- References
- Further reading
- External links
{{Infobox drug | drug_name = | INN = | type = | image = Pexidartinib.svg | image_class = skin-invert-image | width = | alt = | caption =
| pronounce = | tradename = Turalio | Drugs.com = | MedlinePlus = a619050 | licence_CA = | licence_EU = | DailyMedID = Pexidartinib | licence_US = | pregnancy_AU = | pregnancy_AU_comment = | pregnancy_category = | routes_of_administration = By mouth | class = | ATCvet = | ATC_prefix = L01 | ATC_suffix = EX15
Excerpted from Wikipedia’s “pexidartinib” article, available under the CC BY-SA 4.0 licence.