phenacetin
Sign in to savePhenacetin (; acetophenetidin, '''N-(4-ethoxyphenyl)acetamide''') is a pain-relieving and fever-reducing drug, which was widely used following its introduction in 1887. It was withdrawn from medicinal use as dangerous from the 1970s (e.g., withdrawn in Canada in 1973, and by the U.S. Food and Drug Administration in 1983).
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11 sectionsContents
- History
- Known mechanism of action
- Preparation
- Uses
- Medical
- Other
- Safety
- In popular culture
- See also
- References
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Phenacetin (; acetophenetidin, '''N-(4-ethoxyphenyl)acetamide''') is a pain-relieving and fever-reducing drug, which was widely used following its introduction in 1887. It was withdrawn from medicinal use as dangerous from the 1970s (e.g., withdrawn in Canada in 1973, and by the U.S. Food and Drug Administration in 1983).
==History== Phenacetin was introduced in 1887 in Elberfeld, Germany by German company Bayer, and was used principally as an analgesic; it was one of the first synthetic fever reducers to go on the market. It is also known historically to be one of the first non-opioid analgesics without anti-inflammatory properties. Although paracetamol (acetaminophen) was produced earlier, a historical accident saw it ignored after Joseph von Mering's 1893 assessment.