Structure via PubChem · Public domain (PubChem)
pholedrine
Sign in to savePholedrine, also known as '4-hydroxy-N-methylamphetamine and sold under the brand names Paredrinol, Pulsotyl, and Veritol' among others, is a sympathomimetic drug used in topical eye drops to dilate the pupil. It can be used to diagnose Horner's syndrome.
Chemical data
- Formula
- C10H15NO
- Molecular weight
- 165.23 g/mol
- IUPAC name
- 4-[2-(methylamino)propyl]phenol
- SMILES
- CC(CC1=CC=C(C=C1)O)NC
- InChIKey
- SBUQZKJEOOQSBV-UHFFFAOYSA-N
- XLogP
- 1.7
- Polar surface area
- 32.3 Ų
- H-bond donors
- 2
- H-bond acceptors
- 2
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Phase 2
- Molecule type
- Small molecule
via ChEMBL · EBI
Research
151 papers- Pholedrine is a marker of direct disposal of methamphetamine.The Science of the total environment · 2021
- Teratogenic potential of pholedrine: a sympathomimetic vasoconstrictive drug - a population-based case-control study.Congenital anomalies · 2010
- Pholedrine: a substitute for hydroxyamphetamine as a diagnostic eyedrop test in Horner's syndrome.Journal of neurology, neurosurgery, and psychiatry · 1995
- [Pholedrine for determining the site of Horner syndrome].Klinische Monatsblatter fur Augenheilkunde · 1994
- Interaction of the indirectly acting topical sympathomimetics cocaine and pholedrine.German journal of ophthalmology · 1996
via PubMed
Wikidata facts
- Mass
- 165.115
Show 3 more facts
- canonical SMILES
- CC(CC1=CC=C(C=C1)O)NC
- chemical formula
- C₁₀H₁₅NO
- subject has role
- stimulant
Sources (2)
via Wikidata · CC0
~2 min read
Encyclopedic overview
8 sectionsContents
- Pharmacology
- Pharmacodynamics
- Chemistry
- History
- Society and culture
- Names
- Other drugs
- References
Pholedrine, also known as '4-hydroxy-N-methylamphetamine and sold under the brand names Paredrinol, Pulsotyl, and Veritol' among others, is a sympathomimetic drug used in topical eye drops to dilate the pupil. It can be used to diagnose Horner's syndrome.
In 2004, it remained marketed only in Germany.
Excerpted from Wikipedia’s “pholedrine” article, available under the CC BY-SA 4.0 licence.