Phosphodiesterase 5A

Also known as cGMP-specific phosphodiesterase type 5A, cGMP-specific 3',5'-cyclic phosphodiesterase, PDE5A, cGMP-binding cGMP-specific 3',5'-cyclic nucleotide phosphodiesterase, cGMP-binding cGMP-specific phosphodiesterase, phosphodiesterase 5A, cGMP-specific, phosphodiesterase isozyme 5, CGB-PDE

mammalian protein found in Homo sapiens

Protein · UniProt

cGMP-specific 3',5'-cyclic phosphodiesterase

Gene: PDE5A
Organism: Homo sapiens (Human)
Length: 875 aa
Molecular mass: 99,985 Da
Evidence: 1: Evidence at protein level

Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. This phosphodiesterase catalyzes the specific hydrolysis of cGMP to 5'-GMP (PubMed:15489334, PubMed:9714779). Specifically regulates nitric-oxide-generated cGMP (PubMed:15489334)

3D-structureAllosteric enzymeAlternative splicingcGMPcGMP-bindingHydrolaseMetal-bindingNucleotide-binding

View on UniProt →

Swiss-Prot (reviewed) · via UniProt

Clinical Trials

93 registered

PHASE2COMPLETED
A Phase 2, Placebo-Controlled Study To Evaluate The Efficacy And Safety Of PF-00489791 In Patients With Type 2 Diabetes And Overt NephropathyPfizer · NCT01200394
PHASE4UNKNOWN
Long Acting Phosphodiesterase 5 Inhibitors as Add-on Therapy for Patients With Pulmonary Hypertension Treated With Prostanoids.Rabin Medical Center · NCT00705588
PHASE1TERMINATED
Study of Low Dose Nesiritide With or Without Sildenafil in Congestive Heart Failure Patients With Renal DysfunctionMayo Clinic · NCT00818701
NACOMPLETED
Solifenacin Plus Tadalafil vs Solifenacin Alone for Overactive Bladder in FemalesAin Shams University · NCT07312955
NAUNKNOWN
Hypersensitivity to Phosphodiesterase 5 Inhibition in Post-Traumatic HeadacheDanish Headache Center · NCT05669885
COMPLETED
Satisfaction With Phosphodiesterase 5 Inhibitors Treatment In Patients With Cardiovascular RiskPfizer's Upjohn has merged with Mylan to form Viatris Inc. · NCT00874185

via ClinicalTrials.gov

Wikidata facts

Instance of: protein
Image: Protein PDE5A PDB 3BJC.png

Show 4 more facts

found in taxon: Homo sapiens
exact match: purl.uniprot.org/uniprot/O76074
EC enzyme number: 3.1.4.35
Commons category: Phosphodiesterase 5

Sources (6)

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