phospholipase A1
Sign in to saveAlso known as PS-PLA1, phospholipase A1 member A, PLA1, phosphatidylserine-specific phospholipase A1, phosphatidylserine-specific phospholipase A1-alpha
mammalian protein found in Homo sapiens
In the Vinony graph
Within Vinony's link graph, phospholipase A1 is referenced by 449 other articles, and connects out to PubMed, PubMed Central and International Standard Book Number.
Vinony files it under EC 3.1.1, Genes on human chromosome 3 and Peripheral membrane proteins.
Its subject is documented across 9 Wikipedia language editions.
Protein · UniProt
Phospholipase A1 member A
- Gene
- PLA1A
- Organism
- Homo sapiens (Human)
- Length
- 456 aa
- Molecular mass
- 49,715 Da
- Evidence
- 1: Evidence at protein level
Hydrolyzes the ester bond of the acyl group attached at the sn-1 position of phosphatidylserines (phospholipase A1 activity) and 1-acyl-2-lysophosphatidylserines (lysophospholipase activity) in the pathway of phosphatidylserines acyl chain remodeling (PubMed:10196188). Cleaves phosphatidylserines exposed on the outer leaflet of the plasma membrane of apoptotic cells producing 2-acyl-1-lysophosphatidylserines, which in turn enhance mast cell activation and histamine production (By similarity). Has no activity toward other glycerophospholipids including phosphatidylcholines, phosphatidylethan…
Swiss-Prot (reviewed) · via UniProt
Clinical Trials
1 registered- NACOMPLETEDGenetic Markers and Proliferative Diabetic RetinopathyCHU de Reims · NCT02879422
Wikidata facts
- Instance of
- protein
- Part of
- vitellogenins
Show 3 more facts
- found in taxon
- Homo sapiens
- exact match
- purl.uniprot.org/uniprot/Q53H76
- cell component
- extracellular space
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