phospholipase A1

Also known as PS-PLA1, phospholipase A1 member A, PLA1, phosphatidylserine-specific phospholipase A1, phosphatidylserine-specific phospholipase A1-alpha

mammalian protein found in Homo sapiens

Protein · UniProt

Phospholipase A1 member A

Gene: PLA1A
Organism: Homo sapiens (Human)
Length: 456 aa
Molecular mass: 49,715 Da
Evidence: 1: Evidence at protein level

Hydrolyzes the ester bond of the acyl group attached at the sn-1 position of phosphatidylserines (phospholipase A1 activity) and 1-acyl-2-lysophosphatidylserines (lysophospholipase activity) in the pathway of phosphatidylserines acyl chain remodeling (PubMed:10196188). Cleaves phosphatidylserines exposed on the outer leaflet of the plasma membrane of apoptotic cells producing 2-acyl-1-lysophosphatidylserines, which in turn enhance mast cell activation and histamine production (By similarity). Has no activity toward other glycerophospholipids including phosphatidylcholines, phosphatidylethan…

Alternative splicingDisulfide bondGlycoproteinHydrolaseLipid degradationLipid metabolismProteomics identificationReference proteome

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Swiss-Prot (reviewed) · via UniProt