Plektin

Protein · UniProt

Plectin

Gene

PLEC

Organism

Homo sapiens (Human)

Length

4,684 aa

Molecular mass

531,791 Da

Evidence

1: Evidence at protein level

Interlinks intermediate filaments with microtubules and microfilaments and anchors intermediate filaments to desmosomes or hemidesmosomes. Could also bind muscle proteins such as actin to membrane complexes in muscle. May be involved not only in the filaments network, but also in the regulation of their dynamics. Structural component of muscle. Isoform 9 plays a major role in the maintenance of myofiber integrity

• RECRUITING
  Congenital Muscle Disease Study of Patient and Family Reported Medical InformationCure CMD · NCT01403402
• PHASE1/PHASE2COMPLETED
  A Phase 1/2, First-in-Human, Open Label, Dose Escalation Study Of A CSP Targeting Functional Antibody in Solid TumorsZielBio, Inc. · NCT05074472
• NOT_YET_RECRUITING
  Cell-Surface Plectin in the Diagnosis of Cholangiocarcinoma from ERCP-directed Biliary SamplesUniversity of Virginia · NCT06651346

via ClinicalTrials.gov

Wikidata facts

Instance of

protein

Has part

SH3 domain

via Wikidata · CC0