Plectina
Sign in to saveAlso known as Plectin-1, hemidesmosomal protein 1, PLEC, plectin 1, intermediate filament binding protein 500kDa, plectin, HD1
proteina umana
Protein · UniProt
Plectin
- Gene
- PLEC
- Organism
- Homo sapiens (Human)
- Length
- 4,684 aa
- Molecular mass
- 531,791 Da
- Evidence
- 1: Evidence at protein level
Interlinks intermediate filaments with microtubules and microfilaments and anchors intermediate filaments to desmosomes or hemidesmosomes. Could also bind muscle proteins such as actin to membrane complexes in muscle. May be involved not only in the filaments network, but also in the regulation of their dynamics. Structural component of muscle. Isoform 9 plays a major role in the maintenance of myofiber integrity
3D-structureAcetylationActin-bindingAlternative splicingCell junctionCell projectionCoiled coilCytoplasm
View on UniProt →
Swiss-Prot (reviewed) · via UniProt
Clinical Trials
3 registered- RECRUITINGCongenital Muscle Disease Study of Patient and Family Reported Medical InformationCure CMD · NCT01403402
- PHASE1/PHASE2COMPLETEDA Phase 1/2, First-in-Human, Open Label, Dose Escalation Study Of A CSP Targeting Functional Antibody in Solid TumorsZielBio, Inc. · NCT05074472
- NOT_YET_RECRUITINGCell-Surface Plectin in the Diagnosis of Cholangiocarcinoma from ERCP-directed Biliary SamplesUniversity of Virginia · NCT06651346
Wikidata facts
- Instance of
- protein
- Has part
- SH3 domain
Show 3 more facts
- P352
- Óscar Tabárez
- cell component
- extracellular exosome
- found in taxon
- Homo sapiens
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