PPM1D

Also known as PP2C-DELTA, WIP1, protein phosphatase, Mg2+/Mn2+ dependent 1D, IDDGIP, JDVS, WIP1 protein, human, PPM1D protein, human

Protein phosphatase 1D is an enzyme that in humans is encoded by the PPM1D gene.

Gene data

PPM1D

Name: protein phosphatase, Mg2+/Mn2+ dependent 1D
Type: protein-coding
Aliases: IDDGIP, JDVS, PP2C-DELTA, WIP1

The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. The expression of this gene is induced in a p53-dependent manner in response to various environmental stresses. While being induced by tumor suppressor protein TP53/p53, this phosphatase negatively regulates the activity of p38 MAP kinase, MAPK/p38, through which it reduces the phosphorylation of p53, and in turn suppresses p53-mediated transcription and apoptosis. This phosphatase thus mediates a feedback regulation of p38-p53 signaling that contributes to growth inhibition and the suppression of stress induced apoptosis. This gene is located in a chromosomal region known to be amplified in breast cancer. The amplification of this gene has been detected in both breast cancer cell line and primary breast tumors, which suggests a role of this gene in cancer development. [provided by RefSeq, Jul 2008].

via MyGene.info

Research

612 papers

Gain-of-function PPM1D mutations attenuate ischemic stroke.Cell death and differentiation · 2025
PPM1D activity promotes cellular transformation by preventing senescence and cell death.Oncogene · 2024
PPM1D modulates hematopoietic cell fitness and response to DNA damage and is a therapeutic target in myeloid malignancy.Blood · 2023
Jansen-de Vries syndrome: Expansion of the PPM1D clinical and phenotypic spectrum in 34 families.American journal of medical genetics. Part A · 2023
The role of the PPM1D gene in tumor pathogenesis.Biomeditsinskaia khimiia · 2025

via PubMed

Wikidata facts

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HomoloGene ID: 31185
exact match: identifiers.org/ncbigene/8493
genomic end: 58741849
genomic start: 60600193
cytogenetic location: 17q23.2

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Protein phosphatase 1D is an enzyme that in humans is encoded by the PPM1D gene.

The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. The expression of this gene is induced in a p53-dependent manner in response to various environmental stresses. While being induced by tumor suppressor protein TP53/p53, this phosphatase negatively regulates the activity of p38 MAP kinase (MAPK/p38) through which it reduces the phosphorylation of p53, and in turn suppresses p53-mediated transcription and apoptosis. This phosphatase thus mediates a feedback regulation of p38-p53 signaling that contributes to growth inhibition and the suppression of stress induced apoptosis. This gene is located in a chromosomal region known to be amplified in breast cancer. The amplification of this gene has been detected in both breast cancer cell line and primary breast tumors, which suggests a role of this gene in cancer development. Pathogenic variants in exons 5-6 in the PPM1D gene can cause the neurodevelopmental disorder known as Jansen-de Vries Syndrome (JdVS).