Structure via PubChem · Public domain (PubChem)
pramipexole
Sign in to saveAlso known as (-)-pramipexole, (S)-N 6-propyl-4,5,6,7-tetrahydro-1,3-benzothiazole-2,6-diamine, (S)-4,5,6,7-tetrahydro-N(6)-propyl-2,6-benzothiazolediamine
Pramipexole, sold under the brand Mirapex among others, is a medication used to treat Parkinson's disease and restless legs syndrome. In Parkinson's disease it may be used alone or together with levodopa. It is taken by mouth. Pramipexole is a dopamine agonist of the non-ergoline class.
Key facts
- Drug.Watchedfields
- changed
- Drug.verifiedrevid
- 464213026
- Drug.image
- Pramipexole.svg
- Drug.image_class
- skin-invert-image
- Drug.image2
- Pramipexole 3D-Structure Xtal.png
- Drug.image_class2
- bg-transparent
- Drug.tradename
- Mirapex, Mirapexin, Sifrol, others
- Drug.MedlinePlus
- a697029
- Drug.DailyMedID
- Pramipexole
- Drug.pregnancy_AU
- B3
- Drug.routes_of_administration
- By mouth
- Drug.class
- Dopamine receptor agonist; Dopamine D2-like receptor agonist; Antiparkinsonian agent
- Drug.ATC_prefix
- N04
- Drug.ATC_suffix
- BC05
- Drug.legal_BR
- C1
- Drug.legal_CA
- Rx-only
- Drug.legal_US
- Rx-only
- Drug.legal_EU
- Rx-only
via Wikipedia infobox
Chemical data
- Formula
- C10H17N3S
- Molecular weight
- 211.33 g/mol
- IUPAC name
- (6S)-6-N-propyl-4,5,6,7-tetrahydro-1,3-benzothiazole-2,6-diamine
- SMILES
- CCCN[C@H]1CCC2=C(C1)SC(=N2)N
- InChIKey
- FASDKYOPVNHBLU-ZETCQYMHSA-N
- XLogP
- 1.9
- Polar surface area
- 79.2 Ų
- H-bond donors
- 2
- H-bond acceptors
- 4
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Approved
- Molecule type
- Small molecule
- First approval
- 1997
- Admin. routes
- oral
- Indications
- Tourette syndrome, restless legs syndrome, essential tremor, eating disorder
via ChEMBL · EBI
Wikidata facts
- Mass
- 211.114
- Has use
- medication
Show 10 more facts
- chemical formula
- C₁₀H₁₇N₃S
- medical condition treated
- restless legs syndrome
- isomeric SMILES
- CCCN[C@H]1CCC2=C(C1)SC(=N2)N
- canonical SMILES
- CCCNC1CCC2=C(C1)SC(=N2)N
- World Health Organisation international non-proprietary name
- pramipexole
- defined daily dose
- 2.5
- subject has role
- antioxidant
- Commons category
- Pramipexole
- physically interacts with
- Dopamine receptor D3
- significant drug interaction
- (RS)-sulpiride
via Wikidata · CC0
~13 min read
Encyclopedic overview
16 sectionsContents
- Medical uses
- Side effects
- Pharmacology
- Chemistry
- Synthesis
- Analogues
- Society and culture
- Brand names
- Research
- Further Parkinson's disease symptoms treatment
- Cerebral ischemia and reperfusion injury
- Traumatic brain injury
- Psychiatry
- Other indications
- Notes
- References
Pramipexole, sold under the brand Mirapex among others, is a medication used to treat Parkinson's disease and restless legs syndrome. In Parkinson's disease it may be used alone or together with levodopa. It is taken by mouth. Pramipexole is a dopamine agonist of the non-ergoline class.
Pramipexole was approved for medical use in the United States in 1997 and was first manufactured by Pharmacia and Upjohn. It is available as a generic medication. In 2023, it was the 201st most commonly prescribed medication in the United States, with more than 2million prescriptions.
Excerpted from Wikipedia’s “pramipexole” article, available under the CC BY-SA 4.0 licence.