pranlukast

Also known as ONO RS-411, ONO-RS 411

Pranlukast (brand name Onon, オノン) is a cysteinyl leukotriene receptor-1 antagonist. This drug works similarly to Merck & Co.'s montelukast (Singulair). It is widely used in Japan.

Key facts

Drug.PubChem: 4887
Drug.Watchedfields: changed
Drug.verifiedrevid: 464213227
Drug.IUPAC_name: N-[4-oxo-2-(1H-tetrazol-5-yl)-4H-chromen-8-yl]-4-(4-phenylbutoxy)benzamide
Drug.image: Pranlukast.svg
Drug.image_class: skin-invert-image
Drug.tradename: Onon (オノン)
Drug.routes_of_administration: Oral
Drug.metabolism: Hepatic (mainly CYP3A4)
Drug.elimination_half life: 1.5 hours
Drug.IUPHAR_ligand: 3634
Drug.CAS_number: 103177-37-3
Drug.ATC_prefix: R03
Drug.ATC_suffix: DC02
Drug.DrugBank: DB01411
Drug.ChemSpiderID: 4718
Drug.UNII: TB8Z891092
Drug.ChEMBL: 21333

via Wikipedia infobox

Chemical data

Formula: C27H23N5O4
Molecular weight: 481.5 g/mol
IUPAC name: N-[4-oxo-2-(2H-tetrazol-5-yl)chromen-8-yl]-4-(4-phenylbutoxy)benzamide
SMILES: C1=CC=C(C=C1)CCCCOC2=CC=C(C=C2)C(=O)NC3=CC=CC4=C3OC(=CC4=O)C5=NNN=N5
InChIKey: NBQKINXMPLXUET-UHFFFAOYSA-N
XLogP: 4.2
Polar surface area: 119 Å²
H-bond donors: 2
H-bond acceptors: 7
Formal charge: 0

via PubChem

Drug data · ChEMBL

Max clinical phase: Approved
Molecule type: Small molecule
First approval: 1995
Admin. routes: oral
Indications: sinusitis, Airway obstruction, seasonal allergic rhinitis

via ChEMBL · EBI

Research

499 papers

Pranlukast: a review of its use in the management of asthma.Drugs · 2003
Leukotriene receptor antagonists pranlukast and montelukast for treating asthma.Expert opinion on pharmacotherapy · 2014
Metabolite Dysregulation by Pranlukast in Mycobacterium tuberculosis.Molecules (Basel, Switzerland) · 2022
Pranlukast Antagonizes CD49f and Reduces Stemness in Triple-Negative Breast Cancer Cells.Drug design, development and therapy · 2020
Pranlukast treatment and the use of respiratory support in infants with respiratory syncytial virus infection.PloS one · 2022

via PubMed

Wikidata facts

Subclass of: chemical compound
Mass: 481.175004
Has use: medication

Show 2 more facts

chemical formula: C₂₇H₂₃N₅O₄
canonical SMILES: C1=CC=C(C=C1)CCCCOC2=CC=C(C=C2)C(=O)NC3=CC=CC4=C3OC(=CC4=O)C5=NNN=N5

Sources (2)

via Wikidata · CC0

~1 min read

Encyclopedic overview

1 sections

Contents

References

Pranlukast (brand name Onon, オノン) is a cysteinyl leukotriene receptor-1 antagonist. This drug works similarly to Merck & Co.'s montelukast (Singulair). It is widely used in Japan.

Medications of this class, which go under a variety of names according to whether one looks at the American, British or European system of nomenclature, have as their primary function the antagonism of bronchospasm caused, principally in asthmatics, by an allergic reaction to accidentally or inadvertently encountered allergens.

Excerpted from Wikipedia’s “pranlukast” article, available under the CC BY-SA 4.0 licence.

Available in 10 languages

via Wikidata sitelinks · CC0