profilin
Sign in to saveAlso known as PFN, IPR005455
Profilin is an actin-binding protein involved in the dynamic turnover and reconstruction of the actin cytoskeleton. It is found in most eukaryotic organisms. Profilin is important for spatially and temporally controlled growth of actin microfilaments, which is an essential process in cellular locomotion and cell shape changes. This restructuring of the actin cytoskeleton is essential for processes such as organ development, wound healing, and the hunting down of infectious intruders by cells of the immune system.
Key facts
- Protein family.Symbol
- Profilin
- Protein family.Name
- Profilin
- Protein family.image
- Profilin actin complex.png
- Protein family.width
- 250
- Protein family.caption
- Profilin (blue) in complex with actin (green). (PDB code: )
- Protein family.Pfam
- PF00235
- Protein family.InterPro
- IPR002097
- Protein family.SMART
- PROF
- Protein family.PROSITE
- PS00414
- Protein family.SCOP
- 2btf
- Protein family.CDD
- cd00148
via Wikipedia infobox
Research
2,740 papers- Profilin, a Change in the Paradigm.Journal of investigational allergology & clinical immunology · 2018
- Profilin as a dual regulator of actin and microtubule dynamics.Cytoskeleton (Hoboken, N.J.) · 2020
- Profilin 1 and Mitochondria-Partners in the Pathogenesis of Coronary Artery Disease?International journal of molecular sciences · 2021
- Profilin-A master coordinator of actin and microtubule organization in mammalian cells.Journal of cellular physiology · 2021
- Profilin: emerging concepts and lingering misconceptions.Trends in biochemical sciences · 2006
via PubMed
Wikidata facts
Show 1 more fact
- Commons category
- Profilins
Sources (2)
via Wikidata · CC0
~6 min read
Article
8 sectionsContents
- Sources and distribution
- Regulation of actin dynamics
- History of discovery
- Allergen
- Human genes
- References
- Further reading
- External links
Profilin is an actin-binding protein involved in the dynamic turnover and reconstruction of the actin cytoskeleton. It is found in most eukaryotic organisms. Profilin is important for spatially and temporally controlled growth of actin microfilaments, which is an essential process in cellular locomotion and cell shape changes. This restructuring of the actin cytoskeleton is essential for processes such as organ development, wound healing, and the hunting down of infectious intruders by cells of the immune system.
Profilin also binds sequences rich in the amino acid proline in diverse proteins. While most profilin in the cell is bound to actin, profilins have over 50 different binding partners. Many of those are related to actin regulation, but profilin also seems to be involved in activities in the nucleus such as mRNA splicing.