پروگلومید

Chemical data

Formula

C18H26N2O4

Molecular weight

334.4 g/mol

IUPAC name

4-benzamido-5-(dipropylamino)-5-oxopentanoic acid

SMILES

CCCN(CCC)C(=O)C(CCC(=O)O)NC(=O)C1=CC=CC=C1

InChIKey

DGMKFQYCZXERLX-UHFFFAOYSA-N

XLogP

2.4

Polar surface area

86.7 Ų

H-bond donors

2

H-bond acceptors

4

Formal charge

0

via PubChem

Drug data · ChEMBL

Max clinical phase

Approved

Molecule type

Small molecule

Indications

Peptic ulcer, gastroesophageal reflux disease, non-alcoholic steatohepatitis, cirrhosis of liver

via ChEMBL · EBI

• Proglumide Reverses Nonalcoholic Steatohepatitis by Interaction with the Farnesoid X Receptor and Altering the Microbiome.International journal of molecular sciences · 2022
• Isobolographic Analyses of Proglumide-Celecoxib Interaction in Rats with Painful Diabetic Neuropathy.Drug development research · 2017
• Proglumide, a cholecystokinin antagonist, increases gastric emptying in rats.The American journal of physiology · 1987
• Proglumide analogues: potent cholecystokinin receptor antagonists.The American journal of physiology · 1985
• Treatment with a Cholecystokinin Receptor Antagonist, Proglumide, Improves Efficacy of Immune Checkpoint Antibodies in Hepatocellular Carcinoma.International journal of molecular sciences · 2023

via PubMed

Wikidata facts

Subclass of

chemical compound

Mass

334.189257

via Wikidata · CC0