Structure via PubChem · Public domain (PubChem)
promegestone
Sign in to saveAlso known as R5020, 17,21-dimethyl-19-norpregna-4,9(10)-diene-3,20-dione, R 5020, 17alpha-methyl-17-propionylestra-4,9-dien-3-one, RU5020
Promegestone, sold under the brand name Surgestone, is a progestin medication which is used in menopausal hormone therapy and in the treatment of gynecological disorders. It is taken by mouth.
Chemical data
- Formula
- C22H30O2
- Molecular weight
- 326.5 g/mol
- IUPAC name
- (8S,13S,14S,17S)-13,17-dimethyl-17-propanoyl-1,2,6,7,8,11,12,14,15,16-decahydrocyclopenta[a]phenanthren-3-one
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Phase 2
- Molecule type
- Small molecule
via ChEMBL · EBI
Research
837 papers- Use of progestogens and the risk of intracranial meningioma: national case-control study.BMJ (Clinical research ed.) · 2024
- Promegestone Prevents Lipopolysaccharide-Induced Cervical Remodeling in Pregnant Mice.Cells · 2025
- The selective progesterone receptor modulator-promegestone-delays term parturition and prevents systemic inflammation-mediated preterm birth in mice.American journal of obstetrics and gynecology · 2022
- Promegestone (R5020) and mifepristone (RU486) both function as progestational agonists of human glycodelin gene expression in isolated human epithelial cells.The Journal of clinical endocrinology and metabolism · 1998
- [Promegestone, a new progestin].Journal de gynecologie, obstetrique et biologie de la reproduction · 1983
via PubMed
~5 min read
Encyclopedic overview
13 sectionsContents
- Medical uses
- Side effects
- Pharmacology
- Pharmacodynamics
- Pharmacokinetics
- Chemistry
- History
- Society and culture
- Generic names
- Brand names
- Availability
- References
- Further reading
Promegestone, sold under the brand name Surgestone, is a progestin medication which is used in menopausal hormone therapy and in the treatment of gynecological disorders. It is taken by mouth.
Side effects of promegestone include menstrual irregularities among others. Promegestone is a progestin, or a synthetic progestogen, and hence is an agonist of the progesterone receptor, the biological target of progestogens like progesterone. It has weak antiandrogenic, glucocorticoid, and antimineralocorticoid activity and no other important hormonal activity. The medication is largely a prodrug of trimegestone.
Excerpted from Wikipedia’s “promegestone” article, available under the CC BY-SA 4.0 licence.
Available in 7 languages
via Wikidata sitelinks · CC0