proxibarbal
Sign in to saveProxibarbital (Ipronal) is a barbiturate derivative synthesized in 1956 in Poland by Bogusław Bobrański. It has anti-anxiety and sedative properties and is, in contrast to most barbiturates, almost without hypnotic action. It was used as a sedative and anti-anxiety drug. It was also used in the treatment of migraine headaches in a similar manner to butalbital. It was a prescription drug available in Poland from the 1950s to the 1990s under trade name Ipronal.
Chemical data
- Formula
- C10H14N2O4
- Molecular weight
- 226.23 g/mol
- IUPAC name
- 5-(2-hydroxypropyl)-5-prop-2-enyl-1,3-diazinane-2,4,6-trione
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Research
18 papers- Pharmacokinetics of 14C-2-allophanyl-2-allyl -gamma-valero-lactone: a prodrug of proxibarbal in rats.European journal of drug metabolism and pharmacokinetics · 1981
- Isomerisation and urinary excretion of proxibarbal and valofan in man; a preliminary study.European journal of drug metabolism and pharmacokinetics · 1984
- [Thrombopenic purpura caused by proxibarbal].La Revue de medecine interne · 1993
- [Development of proxibarbal blood levels. The role of various elimination processes].Journal de pharmacologie · 1984
- [A controlled trial of prevention of recurrence of gastroduodenal ulcers with proxybarbital].Polski tygodnik lekarski (Warsaw, Poland : 1960) · 1989
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Article
1 sectionsContents
- References
Proxibarbital (Ipronal) is a barbiturate derivative synthesized in 1956 in Poland by Bogusław Bobrański. It has anti-anxiety and sedative properties and is, in contrast to most barbiturates, almost without hypnotic action. It was used as a sedative and anti-anxiety drug. It was also used in the treatment of migraine headaches in a similar manner to butalbital. It was a prescription drug available in Poland from the 1950s to the 1990s under trade name Ipronal.
Valofane isomerizes to proxibarbal in vivo.