PSTPIP2
Sign in to saveAlso known as MAYP, proline-serine-threonine phosphatase interacting protein 2
Proline-serine-threonine phosphatase-interacting protein 2 is an enzyme that in humans is encoded by the PSTPIP2 gene. This protein, also known as macrophage F-actin-associated and tyrosine phosphorylated protein (MAYP) is a member of the Pombe Cdc15 homology (PCH) family of proteins has been shown to coordinate membrane and cytoskeletal dynamics
In the Vinony graph
Within Vinony's link graph, PSTPIP2 is referenced by 3 other articles, and connects out to inflammation, PubMed and macrophage.
It is catalogued under the topic Genes on human chromosome 18.
Its subject is documented across 6 Wikipedia language editions.
Gene data
PSTPIP2- Name
- proline-serine-threonine phosphatase interacting protein 2
- Type
- protein-coding
- Position
- 45,983,536–46,072,367 (−)
- Aliases
- MAYP
- Ensembl
- ENSG00000152229
- RefSeq RNA
- NM_024430.4
- RefSeq protein
- NP_077748.3
Predicted to enable actin filament binding activity. Predicted to be involved in actin filament polymerization. Predicted to be located in cytoskeleton and membrane. Predicted to be active in actin filament; cytoplasm; and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology
Cellular component
via MyGene.info
Gene · Ensembl
proline-serine-threonine phosphatase interacting protein 2
- Symbol
- PSTPIP2
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 18:45,983,536-46,072,367
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
Show 8 more facts
- HomoloGene ID
- 69150
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/9050
- genomic end
- 43652238
- genomic start
- 43563502
- chromosome
- human chromosome 18
- cytogenetic location
- 18q21.1|tdb7990
- expressed in
- biceps brachii
Sources (3)
via Wikidata · CC0
~2 min read
Encyclopedic overview
6 sectionsContents
- Function
- Cytokine expression profile
- Disease linkage
- Interactions
- References
- Further reading
Proline-serine-threonine phosphatase-interacting protein 2 is an enzyme that in humans is encoded by the PSTPIP2 gene. This protein, also known as macrophage F-actin-associated and tyrosine phosphorylated protein (MAYP) is a member of the Pombe Cdc15 homology (PCH) family of proteins has been shown to coordinate membrane and cytoskeletal dynamics
== Function == Pstpip2 is selectively expressed in macrophages and macrophage precursors, and it is an actin bundling protein which regulates filopodia formation and macrophage motility
Excerpted from Wikipedia’s “PSTPIP2” article, available under the CC BY-SA 4.0 licence.