Structure via PubChem · Public domain (PubChem)
ピラゾール
Sign in to saveAlso known as 1,2-Diazole, Hpz, 1H-Pyrazol, Pyrazole
Pyrazole is an organic compound with the formula . It is a heterocycle characterized as an azole with a 5-membered ring of three carbon atoms and two adjacent nitrogen atoms, which are in ortho-substitution. Pyrazoles are also a class of compounds that have the ring C3N2 with adjacent nitrogen atoms. Pyrazole itself has few applications but many substituted pyrazoles are of commercial interest. Notable drugs containing a pyrazole ring are celecoxib (celebrex) and the anabolic steroid stanozolol.
Chemical data
- Formula
- C3H4N2
- Molecular weight
- 68.08 g/mol
- IUPAC name
- 1H-pyrazole
- SMILES
- C1=CNN=C1
- InChIKey
- WTKZEGDFNFYCGP-UHFFFAOYSA-N
- XLogP
- 0.3
- Polar surface area
- 28.7 Ų
- H-bond donors
- 1
- H-bond acceptors
- 1
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Molecule type
- Small molecule
via ChEMBL · EBI
Research
76,074 papers- Pyrazole: an emerging privileged scaffold in drug discovery.Future medicinal chemistry · 2023
- Pyrazole Paradigms: Unveiling Synthetic Pathways and Unraveling Anti-Cancer Potential.Medicinal chemistry (Shariqah (United Arab Emirates)) · 2024
- Pyrazole, Pyrazoline, and Fused Pyrazole Derivatives: New Horizons in EGFR-Targeted Anticancer Agents.Chemistry & biodiversity · 2024
- Pyrazole-based analogs as potential antibacterial agents against methicillin-resistance staphylococcus aureus (MRSA) and its SAR elucidation.European journal of medicinal chemistry · 2021
- Pyrazole Scaffold Synthesis, Functionalization, and Applications in Alzheimer's Disease and Parkinson's Disease Treatment (2011-2020).Molecules (Basel, Switzerland) · 2021
via PubMed
Wikidata facts
- Subclass of
- heterocyclic compound
- Has part
- carbon
- Mass
- 68.037
Show 9 more facts
- described by source
- Encyclopædia Britannica 11th edition
- Commons category
- Pyrazole
- chemical formula
- C₃H₄N₂
- canonical SMILES
- C1=CNN=C1
- subject has role
- enzyme inhibitor
- boiling point
- 187
- melting point
- 68
- found in taxon
- liquorice
- has characteristic
- bitterness
via Wikidata · CC0
Article · 日本語
ピラゾール (pyrazole) は、分子式 C3H4N2、分子量 68.07 の複素環式芳香族化合物のアミンの一種である。3つの炭素原子と2つの隣接した窒素原子で芳香性五員環を構成している。化学的に安定であり、人間に対して薬理効果を持つため、自然界での存在が知られていないにもかかわらずアルカロイド類に分類される化合物である。 ピラゾールはα,β-不飽和アルデヒドとヒドラジンとの反応、続く脱水素化により得られる。 ピラゾール誘導体はその活性を生かして鎮痛剤、抗炎症剤、解熱剤、不整脈治療剤、精神安定剤、筋弛緩剤、精神刺激剤、抗痙攣剤、モノアミン酸化酵素阻害剤、抗糖尿病薬、抗菌剤や染毛剤などに使用されている。 ピラゾール類似の構造を持つ化合物としてピラゾリン、ピラゾリジンが挙げられる。
Abstract from DBpedia / Wikipedia · CC BY-SA