pyrilamine

Also known as Anthisan®, mepiramine, mepyramine maleate, pyrilamine tannate, Pyrlex®, N',N'-dimethyl-N-(p-methoxybenzyl)-N-(2-pyridyl)ethylenediamine, N-(p-methoxybenzyl)-N',N'-dimethyl-N-(alpha-pyridyl)ethylenediamine

Mepyramine, also known as pyrilamine, is a first-generation antihistamine, targeting the H1 receptor as an inverse agonist. Mepyramine rapidly permeates the brain, often causing drowsiness.

In the Vinony graph

Within Vinony's link graph, pyrilamine is referenced by 980 other articles, and connects out to cannabinoids, histamine antagonist and topical medication.

Vinony files it under 2-Pyridyl compounds, 4-Methoxyphenyl compounds and Dimethylamino compounds.

Its subject is documented across 16 Wikipedia language editions.

Research

2,541 papers

Physical and biological properties of pyrilamine.Journal of pharmaceutical sciences · 1983
[Research progress of pyrilamine-sensitive H~+/OC antiporter].Yao xue xue bao = Acta pharmaceutica Sinica · 2016
Pyrilamine-sensitive proton-coupled organic cation (H(+)/OC) antiporter for brain-specific drug delivery.Journal of controlled release : official journal of the Controlled Release Society · 2017
Involvement of proton-coupled SLC49A4-mediated transport in the export of lysosomally trapped pyrilamine.Drug metabolism and disposition: the biological fate of chemicals · 2023
Chronic feeding study of pyrilamine in Fischer 344 rats.Fundamental and applied toxicology : official journal of the Society of Toxicology · 1995

via PubMed

Wikidata facts

Mass: 285.184112

Show 3 more facts

chemical formula: C₁₇H₂₃N₃O
canonical SMILES: CN(C)CCN(CC1=CC=C(C=C1)OC)C2=CC=CC=N2
Commons category: Mepyramine

Sources (3)

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Encyclopedic overview

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Contents

See also
References

Mepyramine, also known as pyrilamine, is a first-generation antihistamine, targeting the H1 receptor as an inverse agonist. Mepyramine rapidly permeates the brain, often causing drowsiness. It is often sold as a maleate salt, pyrilamine maleate.

The medication has negligible anticholinergic activity, with 130,000-fold selectivity for the histamine H1 receptor over the muscarinic acetylcholine receptors (for comparison, diphenhydramine had 20-fold selectivity for the H1 receptor).

Excerpted from Wikipedia’s “pyrilamine” article, available under the CC BY-SA 4.0 licence.