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rac-tilidine

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rac-tilidine

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Also known as ethyl 2-(dimethylamino)-1-phenylcyclohex-3-ene-1-carboxylate, rac-ethyl (1*,2*)-2-(dimethylamino)-1-phenylcyclohex-3-ene-1-carboxylate, (±)-tilidine, tilidine racemate

Tilidine, sold under the brand-name Valoron among others, is a synthetic opioid analgesic, used mainly in Belgium, Bulgaria, Germany, Albania, Luxembourg, and South Africa for the treatment of moderate to severe pain, both acute and chronic. Its onset of pain relief after oral administration is about 10-15 minutes and peak relief from pain occurs about 25-50 minutes after administration.

Chemical data

Formula
C17H23NO2
Molecular weight
273.37 g/mol
IUPAC name
ethyl (2R)-2-(dimethylamino)-1-phenylcyclohex-3-ene-1-carboxylate
SMILES
CCOC(=O)C1(CCC=C[C@H]1N(C)C)C2=CC=CC=C2
InChIKey
WDEFBBTXULIOBB-LDCVWXEPSA-N
XLogP
3.1
Polar surface area
29.5 Ų
H-bond donors
0
H-bond acceptors
3
Formal charge
0

via PubChem

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Encyclopedic overview

8 sections
Contents
  • Medical uses
  • Adverse effects
  • Physicochemistry
  • Pharmacology
  • Pharmacokinetics
  • Synthesis
  • References
  • External links

Tilidine, sold under the brand-name Valoron among others, is a synthetic opioid analgesic, used mainly in Belgium, Bulgaria, Germany, Albania, Luxembourg, and South Africa for the treatment of moderate to severe pain, both acute and chronic. Its onset of pain relief after oral administration is about 10-15 minutes and peak relief from pain occurs about 25-50 minutes after administration.

==Medical uses== thumb|left|Tilidine

Excerpted from Wikipedia’s “rac-tilidine” article, available under the CC BY-SA 4.0 licence.

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