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Structure via PubChem · Public domain (PubChem)
radezolid
Sign in to saveRadezolid (INN, codenamed RX-1741) is a novel oxazolidinone antibiotic being developed by Melinta Therapeutics, Inc. for the treatment of bacterial acne.
Chemical data
- Formula
- C22H23FN6O3
- Molecular weight
- 438.5 g/mol
- IUPAC name
- N-[[(5S)-3-[3-fluoro-4-[4-[(2H-triazol-4-ylmethylamino)methyl]phenyl]phenyl]-2-oxo-1,3-oxazolidin-5-yl]methyl]acetamide
- SMILES
- CC(=O)NC[C@H]1CN(C(=O)O1)C2=CC(=C(C=C2)C3=CC=C(C=C3)CNCC4=NNN=C4)F
- InChIKey
- BTTNOGHPGJANSW-IBGZPJMESA-N
- XLogP
- 1.1
- Polar surface area
- 112 Ų
- H-bond donors
- 3
- H-bond acceptors
- 7
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Phase 2
- Molecule type
- Small molecule
- Indications
- pneumonia
via ChEMBL · EBI
Research
40 papers- In vitro activity of radezolid against Enterococcus faecium and compared with linezolid.The Journal of antibiotics · 2020
- Radezolid Is More Effective Than Linezolid Against Planktonic Cells and Inhibits Enterococcus faecalis Biofilm Formation.Frontiers in microbiology · 2020
- Investigation of radezolid interaction with non-canonical chloramphenicol binding site by molecular dynamics simulations.Journal of molecular graphics & modelling · 2021
- Antibacterial and anti-biofilm activity of radezolid against Staphylococcus aureus clinical isolates from China.Frontiers in microbiology · 2023
- Mitoribosome-Targeting Antibiotics Suppress Osteoclastogenesis and Periodontitis-Induced Bone Loss by Blocking Mitochondrial Protein Synthesis.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025
via PubMed
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 438.182
Show 4 more facts
- chemical formula
- C₂₂H₂₃FN₆O₃
- canonical SMILES
- CC(=O)NCC1CN(C(=O)O1)C2=CC(=C(C=C2)C3=CC=C(C=C3)CNCC4=NNN=C4)F
- isomeric SMILES
- CC(=O)NC[C@H]1CN(C(=O)O1)C2=CC(=C(C=C2)C3=CC=C(C=C3)CNCC4=NNN=C4)F
- subject has role
- antibiotic
Sources (2)
via Wikidata · CC0
~1 min read
Encyclopedic overview
2 sectionsContents
- References
- Further reading
{{Drugbox | IUPAC_name = N-{[(5S)-3-(2-fluoro-4′-{[(1H-1,2,3-triazol-5-ylmethyl)amino]methyl}biphenyl-4-yl)-2-oxo-1,3-oxazolidin-5-yl]methyl}acetamide | image = Radezolid.svg | image_class = skin-invert-image | alt = Skeletal formula of radezolid
| tradename = | legal_status = Investigational | routes_of_administration = Intravenous infusion, oral
Excerpted from Wikipedia’s “radezolid” article, available under the CC BY-SA 4.0 licence.