rasburicase
Sign in to saveAlso known as SR-29142, urate oxidase, uricase, elitek
Rasburicase, sold under the brand name Elitek in the US and Fasturtec in the EU, is a medication that helps to clear uric acid from the blood. It is a recombinant version of urate oxidase, an enzyme that metabolizes uric acid to allantoin. Urate oxidase is known to be present in many mammals but does not naturally occur in humans. Rasburicase is produced by a genetically modified Saccharomyces cerevisiae strain. The complementary DNA (cDNA) coding for rasburicase was cloned from a strain of Aspergillus flavus.
Chemical data
Drug data · ChEMBL
- Max clinical phase
- Approved
- Molecule type
- Enzyme
- First approval
- 2001
- Admin. routes
- parenteral
- Indications
- Burkitts lymphoma, diffuse large B-cell lymphoma, leukemia, lymphoma
via ChEMBL · EBI
Wikidata facts
- Has use
- medication
Show 5 more facts
- medical condition treated
- hyperuricemia
- defined daily dose
- 14
- subject has role
- enzyme activator
- legal status (medicine)
- boxed warning
- has characteristic
- biopharmaceutical
Sources (7)
via Wikidata · CC0
~5 min read
Encyclopedic overview
10 sectionsContents
- Medical uses
- Contraindication
- Side effects
- Pharmacology
- Mechanism of Action
- Pharmacodynamics
- Pharmacokinetics
- Society and culture
- Economics
- References
Rasburicase, sold under the brand name Elitek in the US and Fasturtec in the EU, is a medication that helps to clear uric acid from the blood. It is a recombinant version of urate oxidase, an enzyme that metabolizes uric acid to allantoin. Urate oxidase is known to be present in many mammals but does not naturally occur in humans. Rasburicase is produced by a genetically modified Saccharomyces cerevisiae strain. The complementary DNA (cDNA) coding for rasburicase was cloned from a strain of Aspergillus flavus.
Rasburicase () is a tetrameric protein with identical subunits. Each subunit is made up of a single 301 amino acid polypeptide chain with a molecular mass of about 34 kDa. The drug product is a sterile, white to off-white, lyophilized powder intended for intravenous administration following reconstitution with a diluent. Elitek (rasburicase) is supplied in 3 mL and 10 mL colorless, glass vials containing rasburicase at a concentration of 1.5 mg/mL after reconstitution.
Excerpted from Wikipedia’s “rasburicase” article, available under the CC BY-SA 4.0 licence.