Structure via PubChem · Public domain (PubChem)
mesna
Sign in to saveMesna, sold under the brand name Mesnex among others, is a medication used in those taking cyclophosphamide or ifosfamide to decrease the risk of bleeding from the bladder. It is used either by mouth or injection into a vein.
Chemical data
- Formula
- C2H5NaO3S2
- Molecular weight
- 164.18 g/mol
- IUPAC name
- sodium 2-sulfoethanethiolate
- SMILES
- C(CS(=O)(=O)O)[S-].[Na+]
- InChIKey
- XOGTZOOQQBDUSI-UHFFFAOYSA-M
- Polar surface area
- 63.8 Ų
- H-bond donors
- 1
- H-bond acceptors
- 4
- Formal charge
- 0
via PubChem
Research
1,949 papers- Mesna--a short review.Cancer treatment reviews · 1987
- Ifosfamide and mesna.Clinical pharmacy · 1990
- Oral mesna: a review.Seminars in oncology · 1992
- Ifosfamide/mesna encephalopathy.Lancet (London, England) · 1987
- Mesna-induced urticaria.Drug intelligence & clinical pharmacy · 1988
via PubMed
~3 min read
Encyclopedic overview
9 sectionsContents
- Medical uses
- Chemotherapy adjuvant
- Other
- Administration
- Mechanism of action
- Names
- See also
- References
- External links
Mesna, sold under the brand name Mesnex among others, is a medication used in those taking cyclophosphamide or ifosfamide to decrease the risk of bleeding from the bladder. It is used either by mouth or injection into a vein.
Common side effects include headache, vomiting, sleepiness, loss of appetite, cough, rash, and joint pain. Serious side effects include allergic reactions. Use during pregnancy appears to be safe for the baby but this use has not been well studied. Mesna is an organosulfur compound. It works by altering the breakdown products of cyclophosphamide and ifosfamide found in the urine making them less toxic.
Excerpted from Wikipedia’s “mesna” article, available under the CC BY-SA 4.0 licence.