Structure via PubChem · Public domain (PubChem)
probenecid
Sign in to saveAlso known as Probalan®, p-(Dipropylsulfamoyl)benzoic acid, 4-((Dipropylamino)sulfonyl)benzoic acid, Probenecid Acid, Probenecide, 4-(Di-N-propylsulfamoyl)benzoesaeure, Probenecida
Probenecid, also sold under the brand name Probalan, is a medication that increases uric acid excretion in the urine. It is primarily used in treating gout and hyperuricemia.
Key facts
- Drug.verifiedrevid
- 459812016
- Drug.IUPAC_name
- 4-(dipropylsulfamoyl)benzoic acid
- Drug.image
- Probenecid.svg
- Drug.image_class
- skin-invert-image
- Drug.width
- 200
- Drug.image2
- Probenecid ball-and-stick.png
- Drug.image_class2
- bg-transparent
- Drug.width2
- 200
- Drug.tradename
- Probalan
- Drug.MedlinePlus
- a682395
- Drug.legal_status
- Rx only
- Drug.routes_of_administration
- By mouth
- Drug.protein_bound
- 75-95%
- Drug.elimination_half life
- 2-6 hours (dose: 0.5-1 g)
- Drug.excretion
- kidney (77-88%)
- Drug.CAS_number
- 57-66-9
- Drug.ATC_prefix
- M04
- Drug.ATC_suffix
- AB01
via Wikipedia infobox
Chemical data
- Formula
- C13H19NO4S
- Molecular weight
- 285.36 g/mol
- IUPAC name
- 4-(dipropylsulfamoyl)benzoic acid
- SMILES
- CCCN(CCC)S(=O)(=O)C1=CC=C(C=C1)C(=O)O
- InChIKey
- DBABZHXKTCFAPX-UHFFFAOYSA-N
- XLogP
- 3.2
- Polar surface area
- 83.1 Ų
- H-bond donors
- 1
- H-bond acceptors
- 5
- Formal charge
- 0
via PubChem
Research
5,488 papers- Cephalosporin-probenecid drug interactions.Clinical pharmacokinetics · 1993
- Clinical pharmacokinetics of probenecid.Clinical pharmacokinetics · 1981
- The history and future of probenecid.Cardiovascular toxicology · 2012
- Probenecid-clofibrate interaction.Clinical pharmacology and therapeutics · 1981
- Probenecid: an emerging tool for neuroprotection.CNS & neurological disorders drug targets · 2013
via PubMed
~4 min read
Encyclopedic overview
8 sectionsContents
- Medical uses
- Adverse effects
- Drug interactions
- Pharmacology
- Pharmacodynamics
- Pharmacokinetics
- History
- References
Probenecid, also sold under the brand name Probalan, is a medication that increases uric acid excretion in the urine. It is primarily used in treating gout and hyperuricemia.
Probenecid was developed as an alternative to caronamide to competitively inhibit renal excretion of some drugs, thereby increasing their plasma concentration and prolonging their effects.
Excerpted from Wikipedia’s “probenecid” article, available under the CC BY-SA 4.0 licence.