Structure via PubChem · Public domain (PubChem)
trilaciclib
Sign in to saveAlso known as G1T28
Trilaciclib, sold under the brand name Cosela, is a medication used to reduce the frequency of chemotherapy-induced bone marrow suppression.
Chemical data
- Formula
- C24H30N8O
- Molecular weight
- 446.5 g/mol
- IUPAC name
- 4-[[5-(4-methylpiperazin-1-yl)-2-pyridinyl]amino]spiro[1,3,5,11-tetrazatricyclo[7.4.0.02,7]trideca-2,4,6,8-tetraene-13,1'-cyclohexane]-10-one
- SMILES
- CN1CCN(CC1)C2=CN=C(C=C2)NC3=NC=C4C=C5C(=O)NCC6(N5C4=N3)CCCCC6
- InChIKey
- PDGKHKMBHVFCMG-UHFFFAOYSA-N
- XLogP
- 2.6
- Polar surface area
- 91.2 Ų
- H-bond donors
- 2
- H-bond acceptors
- 7
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Approved
- Molecule type
- Small molecule
- First approval
- 2021
- Admin. routes
- parenteral
- Indications
- small cell lung carcinoma, triple-negative breast cancer, angiosarcoma, breast cancer
via ChEMBL · EBI
Wikidata facts
- Subclass of
- chemical compound
- Has use
- medication
Show 4 more facts
- chemical formula
- C₂₄H₃₀N₈O
- subject has role
- protein kinase inhibitors
- Commons category
- Trilaciclib
- canonical SMILES
- CN1CCN(c2ccc(N=c3nc4c(c[nH]3)cc3n4C4(CCCCC4)CNC3=O)nc2)CC1
Sources (2)
via Wikidata · CC0
~3 min read
Encyclopedic overview
4 sectionsContents
- Medical uses
- History
- References
- External links
Trilaciclib, sold under the brand name Cosela, is a medication used to reduce the frequency of chemotherapy-induced bone marrow suppression.
The most common side effects include fatigue; low levels of calcium, potassium and phosphate; increased levels of an enzyme called aspartate aminotransferase; headache; and infection in the lungs (pneumonia).
Excerpted from Wikipedia’s “trilaciclib” article, available under the CC BY-SA 4.0 licence.