RHOBTB2

Also known as DBC2, Rho related BTB domain containing 2, EIEE64, p83, DEE64

Rho-related BTB domain-containing protein 2 is a protein that in humans is encoded by the RHOBTB2 gene.

In the Vinony graph

Vinony's link graph records 231 inbound references to RHOBTB2, and connects out to PubMed, human chromosome 8 and Ensembl genome database project.

It is catalogued under the topic Genes on human chromosome 8.

Vinony links it to 5 Wikipedia language editions.

Gene data

RHOBTB2

Name: Rho related BTB domain containing 2
Type: protein-coding
Position: 22,987,222–23,020,723 (+)
Aliases: DBC2, DEE64, EIEE64, p83
Ensembl: ENSG00000008853
RefSeq RNA: NM_001160036.2, NM_001160037.2, NM_001374791.1, NM_015178.3, XM_047421607.1
RefSeq protein: NP_001153508.1, NP_001153509.1, NP_001361720.1, NP_055993.2, XP_047277563.1

The protein encoded by this gene is a small Rho GTPase and a candidate tumor suppressor. The encoded protein interacts with the cullin-3 protein, a ubiquitin E3 ligase necessary for mitotic cell division. This protein inhibits the growth and spread of some types of breast cancer. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011].

Pathways

Ubiquitin mediated proteolysis - Homo sapiens (human)Signal Transduction Signaling by Rho GTPases RHO GTPase cycle RHOBTB2 GTPase cycle RHOBTB GTPase Cycle Signaling by Rho GTPases, Miro GTPases and RHOBTB3 Rett syndrome causing genes

via MyGene.info

Gene · Ensembl

Rho related BTB domain containing 2

Symbol: RHOBTB2
Biotype: Protein coding
Organism: Homo sapiens
Location: 8:22,987,222-23,020,723
Strand: Forward (+)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Instance of: gene

Show 8 more facts

HomoloGene ID: 22873
found in taxon: Homo sapiens
exact match: identifiers.org/ncbigene/23221
genomic end: 23020509
genomic start: 22844930
chromosome: human chromosome 8
cytogenetic location: 8p21.3
expressed in: anterior cingulate cortex

Sources (3)

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Encyclopedic overview

3 sections

Contents

Clinical significance
References
Further reading

Rho-related BTB domain-containing protein 2 is a protein that in humans is encoded by the RHOBTB2 gene.

RHOBTB2 is a member of the evolutionarily-conserved RhoBTB subfamily of Rho GTPases. For background information on RhoBTBs, see RHOBTB1 (MIM 607351).[supplied by OMIM]

Excerpted from Wikipedia’s “RHOBTB2” article, available under the CC BY-SA 4.0 licence.