Ozagrel (INN) is an antiplatelet agent working as a thromboxane A2 synthesis inhibitor. ==Synthesis== upright=2 The free-radical halogenation of ethyl 4-methylcinnamate (1) with N-bromosuccinimide in the presence of benzoyl peroxide gives ethyl 4-bromomethylcinnamate (2). Alkylation of imidazole (3) with this material gives the ethyl ester (4) of the drug, which is saponified to give ozagrel.
Ozagrel (INN) is an antiplatelet agent working as a thromboxane A2 synthesis inhibitor. ==Synthesis== upright=2 The free-radical halogenation of ethyl 4-methylcinnamate (1) with N-bromosuccinimide in the presence of benzoyl peroxide gives ethyl 4-bromomethylcinnamate (2). Alkylation of imidazole (3) with this material gives the ethyl ester (4) of the drug, which is saponified to give ozagrel.
== References ==
Discovered by embedding cosine similarity (sentence-transformers MiniLM, 384-dim).