ozagrel
Sign in to saveOzagrel (INN) is an antiplatelet agent working as a thromboxane A2 synthesis inhibitor. ==Synthesis== upright=2 The free-radical halogenation of ethyl 4-methylcinnamate (1) with N-bromosuccinimide in the presence of benzoyl peroxide gives ethyl 4-bromomethylcinnamate (2). Alkylation of imidazole (3) with this material gives the ethyl ester (4) of the drug, which is saponified to give ozagrel.
Wikidata facts
- Mass
- 228.09
Show 3 more facts
- chemical formula
- C₁₃H₁₂N₂O₂
- isomeric SMILES
- C1=CC(=CC=C1CN2C=CN=C2)/C=C/C(=O)O
- canonical SMILES
- C1=CC(=CC=C1CN2C=CN=C2)C=CC(=O)O
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2 sectionsContents
- Synthesis
- References
Ozagrel (INN) is an antiplatelet agent working as a thromboxane A2 synthesis inhibitor. ==Synthesis== upright=2 The free-radical halogenation of ethyl 4-methylcinnamate (1) with N-bromosuccinimide in the presence of benzoyl peroxide gives ethyl 4-bromomethylcinnamate (2). Alkylation of imidazole (3) with this material gives the ethyl ester (4) of the drug, which is saponified to give ozagrel.
== References ==