rifalazil
Sign in to saveAlso known as 3'-hydroxy-5'-(4-isobutyl-1-piperazinyl)benzoxazinorifamycin
Rifalazil (also known as KRM-1648 and AMI-1648) is an antibiotic substance that kills bacterial cells by blocking off the β-subunit in RNA polymerase. Rifalazil is used as a treatment for many different diseases. The most common are Chlamydia infection, Clostridioides difficile associated diarrhea (CDAD), and tuberculosis (TB). Using rifalazil and the effects that coincide with taking rifalazil for treating a bacterial disease vary from person to person, as does any drug put into the human body. Food interactions and genetic variation are a few causes for the variation in side effects from the
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 940.4470
Show 4 more facts
- chemical formula
- C₅₁H₆₄N₄O₁₃
- Commons category
- Rifalazil
- isomeric SMILES
- CC1=C(C2=C3C4=C1O[C@@](C4=O)(O/C=C/[C@@H]([C@H]([C@H]([C@@H]([C@@H]([C@@H]([C@H]([C@H](/C=C/C=C(\C(=O)NC(C2=O)=C5OC6=CC(=CC(=C6N=C35)O)N7CCN(CC7)CC(C)C)/C)C)O)C)O)C)OC(=O)C)C)OC)C)O
- canonical SMILES
- CC1=C(C2=C3C4=C1OC(C4=O)(OC=CC(C(C(C(C(C(C(C(C=CC=C(C(=O)NC(C2=O)=C5OC6=CC(=CC(=C6N=C35)O)N7CCN(CC7)CC(C)C)C)C)O)C)O)C)OC(=O)C)C)OC)C)O
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Encyclopedic overview
4 sectionsContents
- Biological properties
- Uses
- Tested diseases for rifalazil treatment
- References
Rifalazil (also known as KRM-1648 and AMI-1648) is an antibiotic substance that kills bacterial cells by blocking off the β-subunit in RNA polymerase. Rifalazil is used as a treatment for many different diseases. The most common are Chlamydia infection, Clostridioides difficile associated diarrhea (CDAD), and tuberculosis (TB). Using rifalazil and the effects that coincide with taking rifalazil for treating a bacterial disease vary from person to person, as does any drug put into the human body. Food interactions and genetic variation are a few causes for the variation in side effects from the use of rifalazil. Its development was terminated in 2013 due to severe side effects.
==Biological properties== Rifalazil works well alone, and in conjunction with other antibiotics alone. In a study conducted in 2005, it was found that combining rifalazil with vancomycin increased bacterial killing by a factor of 3. Rifalazil also has a very long half-life which allows for more infrequent dosages as opposed to frequent small dosages of antibiotics.
Excerpted from Wikipedia’s “rifalazil” article, available under the CC BY-SA 4.0 licence.