Romifidine is a drug that is used in veterinary medicine as a sedative mainly in large animals such as horses, although it may be used in a wide variety of species. It is not used in humans, but is closely related in structure to the commonly used drug clonidine.
Romifidine is a drug that is used in veterinary medicine as a sedative mainly in large animals such as horses, although it may be used in a wide variety of species. It is not used in humans, but is closely related in structure to the commonly used drug clonidine.
Romifidine acts as an agonist at the α2 adrenergic receptor subtype. Side effects can include bradycardia and respiratory depression. It is often used alongside other sedative or analgesic drugs such as ketamine or butorphanol. Yohimbine can be used as an antidote to rapidly reverse the effects. ==Use== Romifidine is licensed for cats and dogs in several countries. Romifidine is licensed for non-meat horses. Romifidine may produce less ataxia during standing sedation than other α2-adrenergic receptor agonists. ==Pharmacology== Romifidine is an α2-adrenergic receptor agonist that binds at a ratio of 340:1 over the imidazoline receptor.
Discovered by embedding cosine similarity (sentence-transformers MiniLM, 384-dim).