romifidine
Sign in to saveRomifidine is a drug that is used in veterinary medicine as a sedative mainly in large animals such as horses, although it may be used in a wide variety of species. It is not used in humans, but is closely related in structure to the commonly used drug clonidine.
Research
190 papers- Comparison of Detomidine or Romifidine in Combination with Morphine for Standing Magnetic Resonance Imaging in Horses.Veterinary sciences · 2024
- Dobutamine use in horses during romifidine and isoflurane anaesthesia.Research in veterinary science · 2024
- Comparative evaluation of sedative and anti-nociceptive effects of epidural romifidine, romifidine-lidocaine, and lidocaine in donkeys (Equus asinus).Frontiers in veterinary science · 2022
- Romifidine and low doses of tiletamine-zolazepam in dogs.Veterinary anaesthesia and analgesia · 2013
- Effects of detomidine or romifidine during maintenance and recovery from isoflurane anaesthesia in horses.Veterinary anaesthesia and analgesia · 2022
via PubMed
Wikidata facts
- Mass
- 256.996
Show 2 more facts
- canonical SMILES
- C1CN=C(N1)NC2=C(C=CC=C2Br)F
- chemical formula
- C₉H₉BrFN₃
Sources (2)
via Wikidata · CC0
~1 min read
Article
4 sectionsContents
- Use
- Pharmacology
- Side effects
- References
Romifidine is a drug that is used in veterinary medicine as a sedative mainly in large animals such as horses, although it may be used in a wide variety of species. It is not used in humans, but is closely related in structure to the commonly used drug clonidine.
Romifidine acts as an agonist at the α2 adrenergic receptor subtype. Side effects can include bradycardia and respiratory depression. It is often used alongside other sedative or analgesic drugs such as ketamine or butorphanol. Yohimbine can be used as an antidote to rapidly reverse the effects. ==Use== Romifidine is licensed for cats and dogs in several countries. Romifidine is licensed for non-meat horses. Romifidine may produce less ataxia during standing sedation than other α2-adrenergic receptor agonists. ==Pharmacology== Romifidine is an α2-adrenergic receptor agonist that binds at a ratio of 340:1 over the imidazoline receptor.
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