Structure via PubChem · Public domain (PubChem)
efaroxan
Sign in to saveEfaroxan is an α2-adrenergic receptor antagonist and antagonist of the imidazoline receptor.
Chemical data
- Formula
- C13H16N2O
- Molecular weight
- 216.28 g/mol
- IUPAC name
- 2-(2-ethyl-3H-1-benzofuran-2-yl)-4,5-dihydro-1H-imidazole
- SMILES
- CCC1(CC2=CC=CC=C2O1)C3=NCCN3
- InChIKey
- RATZLMXRALDSJW-UHFFFAOYSA-N
- XLogP
- 1.7
- Polar surface area
- 33.6 Ų
- H-bond donors
- 1
- H-bond acceptors
- 2
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Phase 2
- Molecule type
- Small molecule
via ChEMBL · EBI
Research
304 papers- Idazoxan and Efaroxan Potentiate the Endurance Performances and the Antioxidant Activity of Ephedrine in Rats.Medicina (Kaunas, Lithuania) · 2021
- Efaroxan, an alpha-2 antagonist, in the treatment of progressive supranuclear palsy.Movement disorders : official journal of the Movement Disorder Society · 1998
- Efaroxan acts peripherally to block the antisecretory and gastroprotective effects of moxonidine in rats.The Journal of pharmacology and experimental therapeutics · 1995
- Characterization of a KATP channel-independent pathway involved in potentiation of insulin secretion by efaroxan.Diabetes · 2001
- Identification of the monomeric G-protein, Rhes, as an efaroxan-regulated protein in the pancreatic beta-cell.British journal of pharmacology · 2002
via PubMed
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 216.126
Show 4 more facts
- Commons category
- Efaroxan
- canonical SMILES
- CCC1(CC2=CC=CC=C2O1)C3=NCCN3
- chemical formula
- C₁₃H₁₆N₂O
- subject has role
- alpha blocker
Sources (2)
via Wikidata · CC0
~1 min read
Encyclopedic overview
4 sectionsContents
- Synthesis
- See also
- References
- External links
Efaroxan is an α2-adrenergic receptor antagonist and antagonist of the imidazoline receptor.
==Synthesis== thumb|center|500px|class=skin-invert-image|Synthesis (Cmp#13): Revised:
Excerpted from Wikipedia’s “efaroxan” article, available under the CC BY-SA 4.0 licence.