NRXN3

Also known as C14orf60, neurexin 3

Neurexin-3-alpha is a protein that in humans is encoded by the NRXN3 gene.

Gene data

NRXN3

Name: neurexin 3
Type: protein-coding
Position: 78,170,373–79,868,291 (+)
Aliases: C14orf60
Ensembl: ENSG00000021645
RefSeq RNA: NM_001105250.3, NM_001272020.2, NM_001330195.2, NM_001366425.1, NM_001366426.1
RefSeq protein: NP_001098720.1, NP_001258949.1, NP_001317124.1, NP_001353354.1, NP_001353355.1

This gene encodes a member of a family of proteins that function in the nervous system as receptors and cell adhesion molecules. Extensive alternative splicing and the use of alternative promoters results in multiple transcript variants and protein isoforms for this gene, but the full-length nature of many of these variants has not been determined. Transcripts that initiate from an upstream promoter encode alpha isoforms, which contain epidermal growth factor-like (EGF-like) sequences and laminin G domains. Transcripts initiating from the downstream promoter encode beta isoforms, which lack EGF-like sequences. Genetic variation at this locus has been associated with a range of behavioral phenotypes, including alcohol dependence and autism spectrum disorder. [provided by RefSeq, Dec 2012].

Pathways

Cell adhesion molecules - Homo sapiens (human)Neuronal System Neuronal System Neurexins and neuroligins Neurexins and neuroligins Protein-protein interactions at synapses Protein-protein interactions at synapses Disruption of postsynaptic signaling by CNV

via MyGene.info

Gene · Ensembl

neurexin 3

Symbol: NRXN3
Biotype: Protein coding
Organism: Homo sapiens
Location: 14:78,170,373-79,868,291
Strand: Forward (+)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Instance of: gene

Show 7 more facts

exact match: identifiers.org/ncbigene/9369
found in taxon: Homo sapiens
genetic association: ALS
genomic end: 79868291
genomic start: 78708734
chromosome: human chromosome 14
cytogenetic location: 14q24.3-q31.1

Sources (6)

via Wikidata · CC0

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Encyclopedic overview

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Contents

References
Further reading

Neurexin-3-alpha is a protein that in humans is encoded by the NRXN3 gene.

Neurexins are a family of proteins that function in the vertebrate nervous system as cell adhesion molecules and receptors. They are encoded by several unlinked genes of which two, NRXN1 and NRXN3, are among the largest known human genes. Three of the genes (NRXN1-3) utilize two alternate promoters and include numerous alternatively spliced exons to generate thousands of distinct mRNA transcripts and protein isoforms. The majority of transcripts are produced from the upstream promoter and encode alpha-neurexin isoforms; a much smaller number of transcripts are produced from the downstream promoter and encode beta-neurexin isoforms. The alpha-neurexins contain epidermal growth factor-like (EGF-like) sequences and laminin G domains, and have been shown to interact with neurexophilins. The beta-neurexins lack EGF-like sequences and contain fewer laminin G domains than alpha-neurexins. NRXN3 is thought to be involved in synaptic plasticity, and polymorphisms in NRXN3 have been linked to genetic predisposition towards a number of conditions such as alcohol or drug addiction, or obesity.

Excerpted from Wikipedia’s “NRXN3” article, available under the CC BY-SA 4.0 licence.