NRXN3
Sign in to saveAlso known as C14orf60, neurexin 3
Neurexin-3-alpha is a protein that in humans is encoded by the NRXN3 gene.
Gene data
NRXN3- Name
- neurexin 3
- Type
- protein-coding
- Aliases
- C14orf60
This gene encodes a member of a family of proteins that function in the nervous system as receptors and cell adhesion molecules. Extensive alternative splicing and the use of alternative promoters results in multiple transcript variants and protein isoforms for this gene, but the full-length nature of many of these variants has not been determined. Transcripts that initiate from an upstream promoter encode alpha isoforms, which contain epidermal growth factor-like (EGF-like) sequences and laminin G domains. Transcripts initiating from the downstream promoter encode beta isoforms, which lack EGF-like sequences. Genetic variation at this locus has been associated with a range of behavioral phenotypes, including alcohol dependence and autism spectrum disorder. [provided by RefSeq, Dec 2012].
via MyGene.info
Gene · Ensembl
neurexin 3
- Symbol
- NRXN3
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 14:78,170,373-79,868,291
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
Show 4 more facts
- exact match
- identifiers.org/ncbigene/9369
- genomic end
- 79868291
- genomic start
- 78708734
- cytogenetic location
- 14q24.3-q31.1
via Wikidata · CC0
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Article
2 sectionsContents
- References
- Further reading
Neurexin-3-alpha is a protein that in humans is encoded by the NRXN3 gene.
Neurexins are a family of proteins that function in the vertebrate nervous system as cell adhesion molecules and receptors. They are encoded by several unlinked genes of which two, NRXN1 and NRXN3, are among the largest known human genes. Three of the genes (NRXN1-3) utilize two alternate promoters and include numerous alternatively spliced exons to generate thousands of distinct mRNA transcripts and protein isoforms. The majority of transcripts are produced from the upstream promoter and encode alpha-neurexin isoforms; a much smaller number of transcripts are produced from the downstream promoter and encode beta-neurexin isoforms. The alpha-neurexins contain epidermal growth factor-like (EGF-like) sequences and laminin G domains, and have been shown to interact with neurexophilins. The beta-neurexins lack EGF-like sequences and contain fewer laminin G domains than alpha-neurexins. NRXN3 is thought to be involved in synaptic plasticity, and polymorphisms in NRXN3 have been linked to genetic predisposition towards a number of conditions such as alcohol or drug addiction, or obesity.