Structure via PubChem · Public domain (PubChem)
(S)-duloxetine
Sign in to saveAlso known as LY248686, LY 248686, (3S)-N-methyl-3-(1-naphthyloxy)-3-(2-thienyl)propan-1-amine, duloxetine
Duloxetine, sold under the brand name Cymbalta among others, is a medication used to treat major depressive disorder, generalized anxiety disorder, obsessive–compulsive disorder, fibromyalgia, neuropathic pain, central sensitization, and other types of chronic pain. It is taken by mouth.
Key facts
- Drug.Verifiedfields
- changed
- Drug.verifiedrevid
- 460765928
- Drug.image
- Duloxetine.svg
- Drug.image_class
- skin-invert-image
- Drug.image2
- Duloxetine-hydrochloride-from-xtal-3D-bs-17.png
- Drug.image_class2
- bg-transparent
- Drug.tradename
- Cymbalta, others
- Drug.MedlinePlus
- a604030
- Drug.DailyMedID
- Duloxetine
- Drug.pregnancy_AU
- B3
- Drug.routes_of_administration
- By mouth
- Drug.class
- Serotonin–norepinephrine reuptake inhibitor (SNRI)
- Drug.ATC_prefix
- N06
- Drug.ATC_suffix
- AX21
- Drug.legal_AU
- S4
- Drug.legal_BR
- C1
- Drug.legal_CA
- Rx-only
- Drug.legal_UK
- POM
via Wikipedia infobox
Chemical data
- Formula
- C18H19NOS
- Molecular weight
- 297.4 g/mol
- IUPAC name
- (3S)-N-methyl-3-naphthalen-1-yloxy-3-thiophen-2-ylpropan-1-amine
- SMILES
- CNCC[C@@H](C1=CC=CS1)OC2=CC=CC3=CC=CC=C32
- InChIKey
- ZEUITGRIYCTCEM-KRWDZBQOSA-N
- XLogP
- 4.3
- Polar surface area
- 49.5 Ų
- H-bond donors
- 1
- H-bond acceptors
- 3
- Formal charge
- 0
via PubChem
Wikidata facts
- Mass
- 297.119
- Has use
- medication
Show 13 more facts
- chemical formula
- C₁₈H₁₉NOS
- significant drug interaction
- linezolid
- medical condition treated
- major depressive disorder
- World Health Organisation international non-proprietary name
- duloxetine
- isomeric SMILES
- CNCC[C@@H](C1=CC=CS1)OC2=CC=CC3=CC=CC=C32
- canonical SMILES
- CNCCC(C1=CC=CS1)OC2=CC=CC3=CC=CC=C32
- Commons category
- Duloxetine
- defined daily dose
- 60
- subject has role
- serotonin–norepinephrine reuptake inhibitor
- legal status (medicine)
- boxed warning
- physically interacts with
- solute carrier family 6 member 4
- different from
- dapoxetine
- stylized name
- DULoxetine
Sources (10)
via Wikidata · CC0
~26 min read
Encyclopedic overview
26 sectionsContents
- Medical uses
- Painful diabetic peripheral neuropathy
- Major depressive disorder
- Generalized anxiety disorder
- Neuropathic pain
- Fibromyalgia and chronic pain
- Stress urinary incontinence
- Contraindications
- Adverse effects
- Sexual dysfunction
- Increased sweating
- Discontinuation syndrome
- Suicidality
- Postmarketing reports
- Pharmacology
- Mechanism of action
- Pharmacokinetics
- Absorption
- Distribution
- Metabolism
- Elimination
- Research directions
- History
- See also
- Explanatory notes
- References
Duloxetine, sold under the brand name Cymbalta among others, is a medication used to treat major depressive disorder, generalized anxiety disorder, obsessive–compulsive disorder, fibromyalgia, neuropathic pain, central sensitization, and other types of chronic pain. It is taken by mouth.
Duloxetine is a serotonin–norepinephrine reuptake inhibitor (SNRI). The precise mechanism for its antidepressant and anxiolytic effects is not known.
Excerpted from Wikipedia’s “(S)-duloxetine” article, available under the CC BY-SA 4.0 licence.