Structure via PubChem · Public domain (PubChem)
(S)-duloxetine
Sign in to saveAlso known as LY248686, LY 248686, (3S)-N-methyl-3-(1-naphthyloxy)-3-(2-thienyl)propan-1-amine, duloxetine
Duloxetine, sold under the brand name Cymbalta among others, is a medication used to treat major depressive disorder, generalized anxiety disorder, obsessive–compulsive disorder, fibromyalgia, neuropathic pain, central sensitization, and other types of chronic pain. It is taken by mouth.
In the Vinony graph
Within Vinony's link graph, (S)-duloxetine is referenced by 839 other articles, and connects out to selective serotonin reuptake inhibitor, SSRI discontinuation syndrome and pharmacokinetics.
It sits within the topics Antidepressants, Chemical articles with multiple CAS registry numbers and Chemical articles with multiple ChEBIs.
Its subject is documented across 33 Wikipedia language editions.
Key facts
- Drug.Verifiedfields
- changed
- Drug.verifiedrevid
- 460765928
- Drug.image
- Duloxetine.svg
- Drug.image_class
- skin-invert-image
- Drug.image2
- Duloxetine-hydrochloride-from-xtal-3D-bs-17.png
- Drug.image_class2
- bg-transparent
- Drug.tradename
- Cymbalta, others
- Drug.MedlinePlus
- a604030
- Drug.DailyMedID
- Duloxetine
- Drug.pregnancy_AU
- B3
- Drug.routes_of_administration
- By mouth
- Drug.class
- Serotonin–norepinephrine reuptake inhibitor (SNRI)
- Drug.ATC_prefix
- N06
- Drug.ATC_suffix
- AX21
- Drug.legal_AU
- S4
- Drug.legal_BR
- C1
- Drug.legal_CA
- Rx-only
- Drug.legal_UK
- POM
via Wikipedia infobox
Chemical data
- Formula
- C18H19NOS
- Molecular weight
- 297.4 g/mol
- IUPAC name
- (3S)-N-methyl-3-naphthalen-1-yloxy-3-thiophen-2-ylpropan-1-amine
- SMILES
- CNCC[C@@H](C1=CC=CS1)OC2=CC=CC3=CC=CC=C32
- InChIKey
- ZEUITGRIYCTCEM-KRWDZBQOSA-N
- XLogP
- 4.3
- Polar surface area
- 49.5 Ų
- H-bond donors
- 1
- H-bond acceptors
- 3
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Approved
- Molecule type
- Small molecule
- First approval
- 2004
- Admin. routes
- oral
- Indications
- diabetes mellitus, stroke, post-traumatic stress disorder, pain
via ChEMBL · EBI
Wikidata facts
- Mass
- 297.119
- Has use
- medication
Show 13 more facts
- chemical formula
- C₁₈H₁₉NOS
- significant drug interaction
- linezolid
- medical condition treated
- major depressive disorder
- World Health Organisation international non-proprietary name
- duloxetine
- isomeric SMILES
- CNCC[C@@H](C1=CC=CS1)OC2=CC=CC3=CC=CC=C32
- canonical SMILES
- CNCCC(C1=CC=CS1)OC2=CC=CC3=CC=CC=C32
- Commons category
- Duloxetine
- defined daily dose
- 60
- subject has role
- serotonin–norepinephrine reuptake inhibitor
- legal status (medicine)
- boxed warning
- physically interacts with
- solute carrier family 6 member 4
- different from
- dapoxetine
- stylized name
- DULoxetine
Sources (10)
via Wikidata · CC0
~26 min read
Encyclopedic overview
26 sectionsContents
- Medical uses
- Painful diabetic peripheral neuropathy
- Major depressive disorder
- Generalized anxiety disorder
- Neuropathic pain
- Fibromyalgia and chronic pain
- Stress urinary incontinence
- Contraindications
- Adverse effects
- Sexual dysfunction
- Increased sweating
- Discontinuation syndrome
- Suicidality
- Postmarketing reports
- Pharmacology
- Mechanism of action
- Pharmacokinetics
- Absorption
- Distribution
- Metabolism
- Elimination
- Research directions
- History
- See also
- Explanatory notes
- References
Duloxetine, sold under the brand name Cymbalta among others, is a medication used to treat major depressive disorder, generalized anxiety disorder, obsessive–compulsive disorder, fibromyalgia, neuropathic pain, central sensitization, and other types of chronic pain. It is taken by mouth.
Duloxetine is a serotonin–norepinephrine reuptake inhibitor (SNRI). The precise mechanism for its antidepressant and anxiolytic effects is not known.
Excerpted from Wikipedia’s “(S)-duloxetine” article, available under the CC BY-SA 4.0 licence.