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GeneQ18040670· pop 5· linked from 489 articles

S1PR5

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Also known as EDG8, Edg-8, S1P5, SPPR-1, SPPR-2, sphingosine-1-phosphate receptor 5

Sphingosine-1-phosphate receptor 5 also known as S1PR5 is a human gene which encodes a G protein-coupled receptor which binds the lipid signaling molecule sphingosine 1-phosphate (S1P). Hence this receptor is also known as S1P5.

Gene data

S1PR5
Name
sphingosine-1-phosphate receptor 5
Type
protein-coding
Position
10,512,742–10,517,981 (−)
Aliases
EDG8, Edg-8, S1P5, SPPR-1, SPPR-2
Ensembl
ENSG00000180739
RefSeq RNA
NM_001166215.2, NM_030760.5
RefSeq protein
NP_001159687.1, NP_110387.1

The lysosphingolipid sphingosine 1-phosphate (S1P) regulates cell proliferation, apoptosis, motility, and neurite retraction. Its actions may be both intracellular as a second messenger and extracellular as a receptor ligand. S1P and the structurally related lysolipid mediator lysophosphatidic acid (LPA) signal cells through a set of G protein-coupled receptors known as EDG receptors. Some EDG receptors (e.g., EDG1; MIM 601974) are S1P receptors; others (e.g., EDG2; MIM 602282) are LPA receptors.[supplied by OMIM, Mar 2008].

Gene Ontology

Pathways

Sphingolipid signaling pathway - Homo sapiens (human)Neuroactive ligand-receptor interaction - Homo sapiens (human)Signal TransductionSignaling by GPCRClass A/1 (Rhodopsin-like receptors)GPCR downstream signallingG alpha (i) signalling eventsLysosphingolipid and LPA receptorsGPCR ligand bindingSignal Transduction of S1P Receptor

via MyGene.info

Gene · Ensembl

sphingosine-1-phosphate receptor 5

Symbol
S1PR5
Biotype
Protein coding
Organism
Homo sapiens
Location
19:10,512,742-10,517,981
Strand
Reverse (−)
Assembly
GRCh38
View on Ensembl →

via Ensembl · EMBL-EBI

~1 min read

Encyclopedic overview

7 sections
Contents
  • Agonists
  • Evolution
  • [[Sequence homology|Paralogues]] for S1PR5 Gene
  • See also
  • References
  • Further reading
  • External links

Sphingosine-1-phosphate receptor 5 also known as S1PR5 is a human gene which encodes a G protein-coupled receptor which binds the lipid signaling molecule sphingosine 1-phosphate (S1P). Hence this receptor is also known as S1P5.

== Agonists == A-971432 Sphingosine 1-phosphate receptor agonists: a patent review (2010-2012)

Excerpted from Wikipedia’s “S1PR5” article, available under the CC BY-SA 4.0 licence.

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