sargramostim
Sign in to saveAlso known as B1 61.012, recombinant GM-CSF, Leukine
Sargramostim, sold under the brand name Leukine among others, is a recombinant granulocyte macrophage colony-stimulating factor (GM-CSF) that functions as an immunostimulator. It is administered via intravenous infusion or via subcutaneous injection.
Key facts
- Drug.O
- 196
- Drug.S
- 8
- Drug.tradename
- Leukine, others
- Drug.MedlinePlus
- a693005
- Drug.DailyMedID
- Sargramostim
- Drug.routes_of_administration
- Intravenous, subcutaneous
- Drug.ATC_prefix
- L03
- Drug.ATC_suffix
- AA09
- Drug.legal_US
- Rx-only
- Drug.CAS_number
- 123774-72-1
- Drug.DrugBank
- DB00020
- Drug.ChemSpiderID
- none
- Drug.UNII
- 5TAA004E22
- Drug.KEGG
- D05803
- Drug.ChEMBL
- 1201670
- Drug.IUPAC_name
- Human granulocyte macrophage colony stimulating factor
- Drug.C
- 639
- Drug.H
- 1006
via Wikipedia infobox
Chemical data
Drug data · ChEMBL
- Max clinical phase
- Approved
- Molecule type
- Protein
- First approval
- 1991
- Admin. routes
- parenteral
- Indications
- Crohn's disease, prostate carcinoma, Congenital pulmonary alveolar proteinosis, leukemia
via ChEMBL · EBI
Research
295 papers- Sargramostim.2006
- Sargramostim and immune checkpoint inhibitors: combinatorial therapeutic studies in metastatic melanoma.Immunotherapy · 2021
- Sargramostim (rhu GM-CSF) as Cancer Therapy (Systematic Review) and An Immunomodulator. A Drug Before Its Time?Frontiers in immunology · 2021
- Sargramostim for Prophylactic Management of Gastrointestinal Immune-Related Adverse Events of Immune Checkpoint Inhibitor Therapy for Cancer.Cancers · 2024
- Sargramostim in acute radiation syndrome.Expert opinion on biological therapy · 2022
via PubMed
~5 min read
Encyclopedic overview
9 sectionsContents
- Medical uses
- Contraindications
- Adverse effects
- Pharmacology
- Chemistry
- History
- Society and culture
- Legal status
- References
Sargramostim, sold under the brand name Leukine among others, is a recombinant granulocyte macrophage colony-stimulating factor (GM-CSF) that functions as an immunostimulator. It is administered via intravenous infusion or via subcutaneous injection.
==Medical uses== Sargramostim is primarily used for myeloid reconstitution after autologous or allogeneic bone marrow transplantation. It is also used to treat neutropenia induced by chemotherapy during the treatment of acute myeloid leukemia. Additionally, it is used as a medical countermeasure for treating people who have been exposed to sufficient radiation to suppress bone marrow myelogenesis.
Excerpted from Wikipedia’s “sargramostim” article, available under the CC BY-SA 4.0 licence.
Available in 11 languages
via Wikidata sitelinks · CC0