File:MercMorphea.JPG · Wikimedia Commons · See Wikimedia Commons
Also known as dermatosclerosis, scleroderma (rheumatic diseases)
Scleroderma is a group of autoimmune diseases that may result in changes to the skin, blood vessels, muscles, and internal organs. The disease can be either localized to the skin or involve other organs as well. Symptoms may include areas of thickened skin, stiffness, feeling tired, and poor blood flow to the fingers or toes with cold exposure. One form of the condition, known as CREST syndrome, classically results in calcium deposits, Raynaud's syndrome, esophageal problems, thickening of the skin of the fingers and toes, and areas of small, dilated blood vessels.
Key facts
- Medical condition.name
- Scleroderma
- Medical condition.image
- MercMorphea.JPG
- Medical condition.caption
- A type of localized scleroderma known as morphea
- Medical condition.field
- Rheumatology
- Medical condition.onset
- Middle age
- Medical condition.types
- Localized, systemic scleroderma
- Medical condition.causes
- Unknown
- Medical condition.risks
- Family history, certain genetic factors, exposure to silica
- Medical condition.diagnosis
- Based on symptoms, skin biopsy, blood tests
- Medical condition.differential
- Mixed connective tissue disease, systemic lupus erythematosus, polymyositis, dermatomyositis
- Medical condition.treatment
- Supportive care
- Medical condition.medication
- Corticosteroids, methotrexate, non-steroidal anti-inflammatory drugs (NSAIDs)
- Medical condition.prognosis
- Localized: Normal life expectancySystemic: Decreased life expectancy
- Medical condition.frequency
- 3 per 100,000 per year (systemic)
via Wikipedia infobox
Wikidata facts
- Subclass of
- disease
- Image
- Scleroderma - UIP - Honeycomb fibrosis Case 221 (7262028900).jpg
Show 7 more facts
- health specialty
- immunology
- Commons category
- Scleroderma
- NCI Thesaurus ID
- C26746
- exact match
- www.orpha.net/ORDO/Orphanet_801
- different from
- Scleroderma
- on focus list of Wikimedia project
- WikiProject Medicine
Sources (7)
via Wikidata · CC0
Article · 中文
硬皮病（英語：Scleroderma），也称全身性硬化症（Systemic sclerosis），根據皮膚侵犯的區域，分為只限皮膚症狀不會侵犯內臟系統的局部型（localized scleroderma）或會侵犯內臟系統的全身性硬化症（Systemic sclerosis；SSc）。這是一种以限制性（limited systemic form）或弥漫性（diffuse systemic form）皮肤增厚、變硬和內臟纤维化为特征的全身性自體免疫疾病。病变特点为皮肤纤维細胞增生明顯、膠原纖維增多及洋葱皮狀外觀上的改变，最终导致皮肤硬化、血管缺血，除皮肤受累外，它也可影响内脏（心、肺和消化道等器官）。女性发病率为男性的3～4倍。 硬皮症皮膚表徵較為明顯，因此大多數人通常較在意皮膚方面的症狀，忽略了真正導致死亡的其實是其他器官如肺部的侵犯，如肺動脈高壓與間質性肺病；其中，最常併發的間質性肺病為肺纖維化，會阻礙肺泡間正常的氣體交換，導致肺功能下降、死亡率增加，無法回復到正常狀態。因此硬皮症患者應隨時留意自己的肺部健康，一旦出現長達2個月的咳、喘或累等症狀，應主動告知醫師。
Abstract from DBpedia / Wikipedia · CC BY-SA