SEC23IP
Sign in to saveAlso known as P125, P125A, MSTP053, SEC23 interacting protein, iPLA1beta
SEC23-interacting protein is a protein that in humans is encoded by the SEC23IP gene.
Gene data
SEC23IP- Name
- SEC23 interacting protein
- Type
- protein-coding
- Aliases
- MSTP053, P125, P125A, iPLA1A, iPLA1beta
This gene encodes a member of the phosphatidic acid preferring-phospholipase A1 family. The encoded protein is localized to endoplasmic reticulum exit sites and plays a critical role in ER-Golgi transport as part of the multimeric coat protein II complex. An orthologous gene in frogs is required for normal neural crest cell development, suggesting that this gene may play a role in Waardenburg syndrome neural crest defects. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Feb 2011].
via MyGene.info
Wikidata facts
Show 5 more facts
- HomoloGene ID
- 38288
- exact match
- identifiers.org/ncbigene/11196
- genomic end
- 119944657
- genomic start
- 119892730
- cytogenetic location
- 10q26.11-q26.12
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SEC23-interacting protein is a protein that in humans is encoded by the SEC23IP gene.
COPII-coated vesicles are involved in protein transport from the Endoplasmic Reticulum to the Golgi Apparatus. The protein encoded by this gene was identified by its interaction with a mouse protein similar to yeast Sec23p, an essential component of the COPII. This protein shares significant similarity with phospholipid-modifying proteins, especially phosphatidic acid preferring-phospholipase A1. Overexpression of this protein has been shown to cause disorganization of the endoplasmic reticulum-Golgi intermediate compartment and Golgi apparatus, which suggests its role in the early secretory pathway.