السيليكتين الالتصاقي

Protein · UniProt

E-selectin

Gene

SELE

Organism

Homo sapiens (Human)

Length

610 aa

Molecular mass

66,655 Da

Evidence

1: Evidence at protein level

Cell-surface glycoprotein having a role in immunoadhesion. Mediates in the adhesion of blood neutrophils in cytokine-activated endothelium through interaction with SELPLG/PSGL1. May have a role in capillary morphogenesis

• P- and E- selectin in venous thrombosis and non-venous pathologies.Journal of thrombosis and haemostasis : JTH · 2022
• Neutrophil cell surface receptors and their intracellular signal transduction pathways.International immunopharmacology · 2013
• Cellular adhesion and the endothelium: E-selectin, L-selectin, and pan-selectin inhibitors.Hematology/oncology clinics of North America · 2014
• Selectin ligands.Proceedings of the National Academy of Sciences of the United States of America · 1994
• E- and P-selectin: differences, similarities and implications for the design of P-selectin antagonists.Chimia · 2011

via PubMed

• PHASE1ACTIVE_NOT_RECRUITING
  Highest Dose of Uproleselan in Combination With Fludarabine and Cytarabine for Patients With Acute Myeloid Leukemia, Myelodysplastic Syndrome, or Mixed Phenotype Acute Leukemia Relapsed or Refractory That Expresses E-selectin Ligand on the Cell MembraneNational Cancer Institute (NCI) · NCT05146739
• PHASE1TERMINATED
  GI-270384 Study In Patients With Mild To Moderate Ulcerative ColitisGlaxoSmithKline · NCT00457171
• PHASE3ENROLLING_BY_INVITATION
  Alpha Lipoic Acid in Pediatrics on HemodialysisAin Shams University · NCT06286098
• PHASE2TERMINATED
  E-Selectin Nasal Spray to Prevent Stroke RecurrenceNational Institute of Neurological Disorders and Stroke (NINDS) · NCT00012454
• NANOT_YET_RECRUITING
  Daily Tadalafil in Diabetic ED PatientsSouth Valley University · NCT06962462
• PHASE1WITHDRAWN
  E-Selectin Nasal Instillation to Prevent Secondary StrokeNational Institute of Neurological Disorders and Stroke (NINDS) · NCT00069069

via ClinicalTrials.gov