E-セレクチン

Also known as SELE, endothelial adhesion molecule 1, ELAM-1, CD62 antigen-like family member E, LECAM2, E-selectin, endothelial leukocyte adhesion molecule 1, Leukocyte-endothelial cell adhesion molecule 2

E-selectin, also known as CD62 antigen-like family member E (CD62E), endothelial-leukocyte adhesion molecule 1 (ELAM-1), or leukocyte-endothelial cell adhesion molecule 2 (LECAM2), is a selectin cell adhesion molecule expressed only on endothelial cells activated by cytokines. Like other selectins, it plays an important part in inflammation. In humans, E-selectin is encoded by the SELE gene.

Research

11,636 papers

P- and E- selectin in venous thrombosis and non-venous pathologies.Journal of thrombosis and haemostasis : JTH · 2022
Neutrophil cell surface receptors and their intracellular signal transduction pathways.International immunopharmacology · 2013
Cellular adhesion and the endothelium: E-selectin, L-selectin, and pan-selectin inhibitors.Hematology/oncology clinics of North America · 2014
Selectin ligands.Proceedings of the National Academy of Sciences of the United States of America · 1994
E- and P-selectin: differences, similarities and implications for the design of P-selectin antagonists.Chimia · 2011

via PubMed

Clinical Trials

8 registered

PHASE1

Article · 日本語

E-セレクチン（英: E-selectin）は、細胞接着分子セレクチンの1種であり、サイトカインによって活性化された血管内皮細胞で発現する。CD62E（CD62 antigen-like family member E）、ELAM-1（endothelial-leukocyte adhesion molecule 1）、LECAM2（leukocyte-endothelial cell adhesion molecule 2）としても知られる。他のセレクチンと同様、炎症に重要な役割を果たす。ヒトでは、E-セレクチンはSELE遺伝子にコードされている。

Abstract from DBpedia / Wikipedia · CC BY-SA