E-セレクチン
Sign in to saveAlso known as SELE, endothelial adhesion molecule 1, ELAM-1, CD62 antigen-like family member E, LECAM2, E-selectin, endothelial leukocyte adhesion molecule 1, Leukocyte-endothelial cell adhesion molecule 2
E-selectin, also known as CD62 antigen-like family member E (CD62E), endothelial-leukocyte adhesion molecule 1 (ELAM-1), or leukocyte-endothelial cell adhesion molecule 2 (LECAM2), is a selectin cell adhesion molecule expressed only on endothelial cells activated by cytokines. Like other selectins, it plays an important part in inflammation. In humans, E-selectin is encoded by the SELE gene.
Protein · UniProt
E-selectin
- Gene
- SELE
- Organism
- Homo sapiens (Human)
- Length
- 610 aa
- Molecular mass
- 66,655 Da
- Evidence
- 1: Evidence at protein level
Cell-surface glycoprotein having a role in immunoadhesion. Mediates in the adhesion of blood neutrophils in cytokine-activated endothelium through interaction with SELPLG/PSGL1. May have a role in capillary morphogenesis
Swiss-Prot (reviewed) · via UniProt
Research
11,636 papers- P- and E- selectin in venous thrombosis and non-venous pathologies.Journal of thrombosis and haemostasis : JTH · 2022
- Neutrophil cell surface receptors and their intracellular signal transduction pathways.International immunopharmacology · 2013
- Cellular adhesion and the endothelium: E-selectin, L-selectin, and pan-selectin inhibitors.Hematology/oncology clinics of North America · 2014
- Selectin ligands.Proceedings of the National Academy of Sciences of the United States of America · 1994
- E- and P-selectin: differences, similarities and implications for the design of P-selectin antagonists.Chimia · 2011
via PubMed
Clinical Trials
8 registered- PHASE1ACTIVE_NOT_RECRUITINGHighest Dose of Uproleselan in Combination With Fludarabine and Cytarabine for Patients With Acute Myeloid Leukemia, Myelodysplastic Syndrome, or Mixed Phenotype Acute Leukemia Relapsed or Refractory That Expresses E-selectin Ligand on the Cell MembraneNational Cancer Institute (NCI) · NCT05146739
- PHASE1TERMINATEDGI-270384 Study In Patients With Mild To Moderate Ulcerative ColitisGlaxoSmithKline · NCT00457171
- PHASE3ENROLLING_BY_INVITATIONAlpha Lipoic Acid in Pediatrics on HemodialysisAin Shams University · NCT06286098
- PHASE2TERMINATEDE-Selectin Nasal Spray to Prevent Stroke RecurrenceNational Institute of Neurological Disorders and Stroke (NINDS) · NCT00012454
- NANOT_YET_RECRUITINGDaily Tadalafil in Diabetic ED PatientsSouth Valley University · NCT06962462
- PHASE1WITHDRAWNE-Selectin Nasal Instillation to Prevent Secondary StrokeNational Institute of Neurological Disorders and Stroke (NINDS) · NCT00069069
Article · 日本語
E-セレクチン（英: E-selectin）は、細胞接着分子セレクチンの1種であり、サイトカインによって活性化された血管内皮細胞で発現する。CD62E（CD62 antigen-like family member E）、ELAM-1（endothelial-leukocyte adhesion molecule 1）、LECAM2（leukocyte-endothelial cell adhesion molecule 2）としても知られる。他のセレクチンと同様、炎症に重要な役割を果たす。ヒトでは、E-セレクチンはSELE遺伝子にコードされている。
Abstract from DBpedia / Wikipedia · CC BY-SA