سروتونین

Key facts

Drug.IUPAC_name

3-(2-Aminoethyl)-1H-indol-5-ol

Drug.synonyms

5-HT, 5-Hydroxytryptamine, Enteramine, Thrombocytin, 3-(β-Aminoethyl)-5-hydroxyl solution, Thrombotonin

Drug.image

Serotonin-2D-skeletal.svg

Drug.image_class

skin-invert-image

Drug.alt

Skeletal formula of serotonin

Drug.image2

Serotonin-Spartan-HF-based-on-xtal-3D-balls-web.png

Drug.image_class2

bg-transparent

Drug.alt2

Ball-and-stick model of the serotonin molecule

Drug.source_tissues

raphe nuclei, enterochromaffin cells

Drug.target_tissues

system-wide

Drug.receptors

5-HT1, 5-HT2, 5-HT3, 5-HT4, 5-HT5, 5-HT6, 5-HT7

Drug.agonists

Indirectly: SSRIs, MAOIs

Drug.precursor

5-HTP

Drug.biosynthesis

Aromatic L-amino acid decarboxylase

Drug.metabolism

MAO

Drug.CAS_number

50-67-9

Drug.PubChem

5202

Drug.ChemSpiderID

5013

via Wikipedia infobox

Chemical data

Formula

C10H12N2O

Molecular weight

176.21 g/mol

IUPAC name

3-(2-aminoethyl)-1H-indol-5-ol

SMILES

C1=CC2=C(C=C1O)C(=CN2)CCN

InChIKey

QZAYGJVTTNCVMB-UHFFFAOYSA-N

XLogP

0.2

Polar surface area

62 Ų

H-bond donors

3

H-bond acceptors

2

Formal charge

0

via PubChem

Drug data · ChEMBL

Max clinical phase

Phase 3

Molecule type

Small molecule

Indications

Chemotherapy-induced nausea and vomiting

via ChEMBL · EBI

• Serotonin Pathway in Cancer.ReviewInternational journal of molecular sciences · 2021Balakrishna P, George S, Hatoum H et al.DOI: 10.3390/ijms22031268
• Serotonin in depression and Alzheimer's disease: Focus on SSRI's beneficial effects.ReviewAgeing research reviews · 2024Tahiri J, Mian M, Aftan F et al.DOI: 10.1016/j.arr.2024.102537
• Serotonin signalling in cancer: Emerging mechanisms and therapeutic opportunities.ReviewClinical and translational medicine · 2024Chen L, Huang S, Wu X et al.DOI: 10.1002/ctm2.1750
• [The pharmacological basis of the serotonin system: Application to antidepressant response].ReviewL'Encephale · 2016David DJ, Gardier AMDOI: 10.1016/j.encep.2016.03.012
• Serotonin, hematopoiesis and stem cells.ReviewPharmacological research · 2019Fouquet G, Coman T, Hermine O et al.DOI: 10.1016/j.phrs.2018.08.005
• Serotonin regulation of mitochondria in kidney diseases.ReviewPharmacological research · 2024Hurtado K, Scholpa NE, Schnellmann JG et al.DOI: 10.1016/j.phrs.2024.107154
• Serotonin and orthodontic tooth movement.ReviewBiochimie · 2019Dhenain T, Côté F, Coman TDOI: 10.1016/j.biochi.2019.04.002
• Serotonin as a Mitogen in the Gastrointestinal Tract: Revisiting a Familiar Molecule in a New Role.ReviewCellular and molecular gastroenterology and hepatology · 2021Shah PA, Park CJ, Shaughnessy MP et al.DOI: 10.1016/j.jcmgh.2021.05.008

via PubMed

Wikidata facts

Has part

hydrogen

Mass

176.095

via Wikidata · CC0