SET domain containing 6 is a protein in humans that is encoded by the SETD6 gene.
SET domain containing 6 is a protein in humans that is encoded by the SETD6 gene.
SETD6 monomethylates the RelA subunit of nuclear factor kappa B (NF-κB). RelA mono-methylation at lysine 310 (RelAK310me1) leads to the constitutive repression of RelA target genes by recruiting the PKMT G9a-like protein (GLP), which catalyzes H3K9me2 and leads to chromatin silencing and gene repression. In response to stimulation with TNFa and lipopolysaccharide, phosphorylation of RelA at serine 311 (RelAS311ph) by PKCzeta physically blocks the interaction between GLP and RelAK310me1, leading to transcription activation.
Discovered by embedding cosine similarity (sentence-transformers MiniLM, 384-dim).