SETD6

Also known as SET domain containing 6, SET domain containing 6, protein lysine methyltransferase

SET domain containing 6 is a protein in humans that is encoded by the SETD6 gene.

In the Vinony graph

Vinony's link graph records 4 inbound references to SETD6, and connects out to PubMed, human chromosome 16 and Ensembl genome database project.

Vinony files it under Genes on human chromosome 16 and Human proteins.

Vinony links it to 5 Wikipedia language editions.

Gene data

SETD6

Name: SET domain containing 6, protein lysine methyltransferase
Type: protein-coding
Position: 58,515,479–58,523,842 (+)
Ensembl: ENSG00000103037
RefSeq RNA: NM_001160305.4, NM_024860.3, NR_134583.1, XM_011523336.2, XM_047434663.1
RefSeq protein: NP_001153777.1, NP_079136.2, XP_011521638.1, XP_047290619.1, XP_047290620.1

This gene encodes a methyltransferase that adds a methyl group to the histone H2AZ, which is involved in nuclear receptor-dependent transcription. The protein also interacts with several endogenous proteins which are involved in nuclear hormone receptor signaling. A related pseudogene is located on chromosome 2. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016].

Pathways

PKMTs methylate histone lysines Chromatin modifying enzymes Chromatin organization Histone Modifications

via MyGene.info

Gene · Ensembl

SET domain containing 6, protein lysine methyltransferase

Symbol: SETD6
Biotype: Protein coding
Organism: Homo sapiens
Location: 16:58,515,479-58,523,842
Strand: Forward (+)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Instance of: gene

Show 8 more facts

HomoloGene ID: 38743
found in taxon: Homo sapiens
exact match: identifiers.org/ncbigene/79918
genomic end: 58523842
genomic start: 58549383
chromosome: human chromosome 16
cytogenetic location: 16q21
expressed in: anterior pituitary

Sources (4)

via Wikidata · CC0

~2 min read

Encyclopedic overview

2 sections

Contents

References
Further reading

SET domain containing 6 is a protein in humans that is encoded by the SETD6 gene.

SETD6 monomethylates the RelA subunit of nuclear factor kappa B (NF-κB). RelA mono-methylation at lysine 310 (RelAK310me1) leads to the constitutive repression of RelA target genes by recruiting the PKMT G9a-like protein (GLP), which catalyzes H3K9me2 and leads to chromatin silencing and gene repression. In response to stimulation with TNFa and lipopolysaccharide, phosphorylation of RelA at serine 311 (RelAS311ph) by PKCzeta physically blocks the interaction between GLP and RelAK310me1, leading to transcription activation.

Excerpted from Wikipedia’s “SETD6” article, available under the CC BY-SA 4.0 licence.