SGSM2
Sign in to saveAlso known as RUTBC1, small G protein signaling modulator 2
Small G protein signaling modulator 2 is a protein that in humans is encoded by the SGSM2 gene.
In the Vinony graph
Within Vinony's link graph, SGSM2 is referenced by 2 other articles, and connects out to PubMed, human chromosome 17 and Ensembl genome database project.
It sits within the topics Genes on human chromosome 17 and Human proteins.
Its subject is documented across 5 Wikipedia language editions.
Gene data
SGSM2- Name
- small G protein signaling modulator 2
- Type
- protein-coding
- Position
- 2,337,488–2,381,058 (+)
- Aliases
- RUTBC1
- Ensembl
- ENSG00000141258
- RefSeq RNA
- NM_001098509.2, NM_001346700.2, NM_014853.3, XM_011524101.4, XM_011524102.4
- RefSeq protein
- NP_001091979.1, NP_001333629.1, NP_055668.2, XP_011522403.1, XP_011522404.1
The protein encoded by this gene is a GTPase activator with activity towards RAB32 and RAB33B, which are regulators of membrane trafficking. The encoded protein inactivates RAB32 and can bind RAB9A-GTP, a protein required for RAB32 activation. [provided by RefSeq, Oct 2016].
Gene Ontology
Biological process
Molecular function
Cellular component
via MyGene.info
Gene · Ensembl
small G protein signaling modulator 2
- Symbol
- SGSM2
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 17:2,337,488-2,381,058
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
Show 8 more facts
- HomoloGene ID
- 14780
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/9905
- genomic end
- 2284352
- genomic start
- 2240792
- chromosome
- human chromosome 17
- cytogenetic location
- 17p13.3
- expressed in
- cingulate gyrus
Sources (4)
via Wikidata · CC0
~1 min read
Encyclopedic overview
3 sectionsContents
- Clinical relevance
- References
- Further reading
Small G protein signaling modulator 2 is a protein that in humans is encoded by the SGSM2 gene.
==Clinical relevance== In a recent genome-wide association study, this gene has been associated with fasting glucose traits, type 2 diabetes and obesity.
Excerpted from Wikipedia’s “SGSM2” article, available under the CC BY-SA 4.0 licence.